EGFR — Abundance_hsp90i

🧬 View Structure

73 interactions

DMS Score Heatmap Scroll horizontally • click a column to see interactions • ■ purple strip = interface positions

TM_ErbB1 PTKc_EGFR A V I L G F Y W C M P S T N Q D E H K R * 680 700 720 740 760 780 800 820 840 860 880 900 920 940 960 980 1000 1020 1040 1060 1080 1100 1180 1200 0.28 1.00 1.50
Click a position to see interactions — ■ orange strip marks interface positions (darker = more interactions)

Significant Interactions

Interactor Predictor Log FC p-value (FDR) Cliff's Delta AUROC Unique Pos. % Unique # Interface Clashes Structure
PPIB Predictomes 0.086 1.12e-03 0.183 0.591 — — 7 0 View 3D
EGF Predictomes 0.145 2.55e-04 0.235 0.618 1 20% 5 0 View 3D
ERRFI1 Predictomes 0.036 4.12e-04 0.120 0.560 — — 25 0 View 3D
SGSM2 Predictomes 0.183 1.96e-06 0.344 0.672 0 0% 4 0 View 3D
EGF Predictomes 0.043 1.78e-02 0.114 0.557 1 20% 10 0 View 3D
ERBB2 Predictomes 0.074 3.35e-05 0.168 0.584 — — 16 0 View 3D
ERBB3 Predictomes -0.034 4.79e-01 -0.028 0.486 — — 19 0 View 3D
ERRFI1 Predictomes 0.046 1.53e-05 0.146 0.573 — — 24 0 View 3D
SGSM2 Predictomes 0.198 5.39e-12 0.338 0.669 0 0% 9 0 View 3D
PPIB Predictomes 0.044 9.81e-04 0.158 0.579 — — 10 0 View 3D
PPIB Predictomes 0.085 1.37e-03 0.180 0.590 — — 7 0 View 3D
ERRFI1 Predictomes 0.058 1.88e-05 0.153 0.577 — — 22 0 View 3D
ABL1 Predictomes -0.034 3.32e-01 -0.074 0.463 — — 4 0 View 3D
LSM11 Zhang_et_al 0.290 2.38e-13 0.602 0.801 0 0% 3 0 View 3D
CTR9 Zhang_et_al 0.123 1.02e-12 0.231 0.616 8 38% 21 0 View 3D
BUB3 Zhang_et_al 0.101 1.80e-02 0.173 0.587 — — 4 0 View 3D
B4GALT1 Zhang_et_al 0.137 4.21e-04 0.297 0.649 2 67% 3 0 View 3D
CD2AP Zhang_et_al -0.030 4.65e-01 -0.040 0.480 — — 10 0 View 3D
SH2B3 Zhang_et_al -0.628 1.22e-41 -0.605 0.197 8 80% 10 0 View 3D
WDR44 Zhang_et_al 0.080 4.55e-05 0.175 0.587 — — 12 0 View 3D
NOTCH2 Zhang_et_al -0.003 8.30e-01 0.017 0.509 4 100% 5 0 View 3D
NOTCH2 Zhang_et_al 0.224 3.04e-11 0.487 0.743 4 100% 4 0 View 3D
NOTCH2 Zhang_et_al -0.041 7.94e-01 0.014 0.507 4 100% 13 0 View 3D
PIK3R4 Zhang_et_al 0.133 5.76e-10 0.269 0.634 3 27% 11 0 View 3D
IARS1 Zhang_et_al 0.107 1.90e-05 0.176 0.588 6 46% 13 0 View 3D
EPS15 Zhang_et_al 0.127 9.34e-08 0.263 0.632 1 11% 9 0 View 3D
LRIG3 Zhang_et_al 0.087 9.15e-04 0.188 0.594 — — 7 0 View 3D
ADAMTS9 Zhang_et_al 0.139 6.64e-11 0.271 0.635 0 0% 12 0 View 3D
ADAMTS9 Zhang_et_al 0.039 3.39e-01 0.064 0.532 0 0% 6 0 View 3D
ITGB2 Zhang_et_al 0.016 3.40e-02 0.113 0.556 — — 9 0 View 3D
MYO9A Zhang_et_al 0.095 4.40e-03 0.147 0.573 — — 9 0 View 3D
CTNNB1 Zhang_et_al 0.157 1.75e-06 0.338 0.669 0 0% 4 0 View 3D
CRKL Zhang_et_al -0.017 3.11e-01 -0.093 0.453 — — 3 0 View 3D
ITGA2B Zhang_et_al 0.051 5.68e-02 0.103 0.551 — — 8 0 View 3D
KAT7 Zhang_et_al 0.114 1.81e-06 0.232 0.616 7 78% 9 0 View 3D
PLAA Zhang_et_al 0.065 1.86e-01 0.104 0.552 — — 4 0 View 3D
CLP1 Zhang_et_al 0.125 7.15e-10 0.268 0.634 2 18% 11 0 View 3D
ATP6V1H Zhang_et_al 0.013 8.30e-01 -0.019 0.490 — — 4 0 View 3D
CBLC Zhang_et_al 0.154 1.77e-09 0.377 0.688 3 60% 5 0 View 3D
FERMT1 Zhang_et_al 0.177 7.42e-13 0.413 0.707 1 17% 6 0 View 3D
ARAF Zhang_et_al 0.064 1.80e-02 0.137 0.568 — — 7 0 View 3D
MLST8 Zhang_et_al 0.079 2.34e-01 0.094 0.547 — — 4 0 View 3D
VAV2 Zhang_et_al -0.361 1.02e-12 -0.500 0.250 3 75% 4 0 View 3D
LRIG1 Zhang_et_al -0.003 6.84e-01 -0.026 0.487 — — 8 0 View 3D
SOS1 Zhang_et_al 0.055 1.04e-02 0.129 0.565 — — 9 0 View 3D
GATB Zhang_et_al 0.197 5.51e-16 0.464 0.732 3 50% 6 0 View 3D
TWF1 Zhang_et_al -0.070 9.55e-02 -0.155 0.423 — — 3 0 View 3D
SOS2 Zhang_et_al 0.185 4.59e-06 0.331 0.665 0 0% 4 0 View 3D
SOS2 Zhang_et_al 0.070 4.42e-02 0.113 0.557 0 0% 8 0 View 3D
CHIA Zhang_et_al 0.107 8.63e-04 0.197 0.599 0 0% 6 0 View 3D
EED Zhang_et_al 0.086 4.86e-02 0.172 0.586 — — 3 0 View 3D
ACOT9 Zhang_et_al 0.082 7.77e-03 0.161 0.581 — — 6 0 View 3D
JPH1 Zhang_et_al 0.075 1.62e-01 0.083 0.541 — — 7 0 View 3D
ANKRD13A Zhang_et_al 0.040 4.96e-01 0.041 0.521 — — 8 0 View 3D
SEL1L Zhang_et_al 0.130 4.09e-06 0.222 0.611 1 10% 10 0 View 3D
NCK1 Zhang_et_al 0.089 9.68e-02 0.149 0.574 — — 3 0 View 3D
JUP Zhang_et_al 0.087 1.02e-02 0.129 0.565 — — 9 0 View 3D
MIOS Zhang_et_al 0.110 9.16e-06 0.266 0.633 2 33% 6 0 View 3D
CTNND1 Zhang_et_al 0.133 6.09e-07 0.253 0.627 2 25% 8 0 View 3D
PTPRF Zhang_et_al 0.063 2.98e-01 0.074 0.537 — — 5 0 View 3D
EGFR RCSB_PDB -0.012 4.72e-01 -0.035 0.483 3 75% 11 0 View 3D
EGFR RCSB_PDB 0.036 2.43e-01 0.053 0.526 3 75% 12 0 View 3D
ERRFI1 RCSB_PDB 0.051 2.25e-05 0.143 0.571 2 15% 23 0 View 3D
ERBB3 RCSB_PDB 0.055 2.55e-06 0.161 0.581 — — 20 0 View 3D
EGFR RCSB_PDB 0.022 8.01e-01 0.013 0.506 3 75% 11 0 View 3D
EGFR RCSB_PDB 0.009 9.05e-01 -0.006 0.497 3 75% 11 0 View 3D
ERBB3 RCSB_PDB 0.078 1.04e-07 0.175 0.588 — — 22 0 View 3D
ERBB3 RCSB_PDB 0.046 1.43e-04 0.131 0.566 — — 20 0 View 3D
EGFR RCSB_PDB -0.301 4.37e-09 -0.407 0.296 3 75% 4 0 View 3D
EGFR RCSB_PDB 0.016 7.97e-01 0.013 0.506 3 75% 12 0 View 3D
EGFR RCSB_PDB 0.002 8.25e-01 -0.011 0.494 3 75% 11 0 View 3D
EGFR RCSB_PDB -0.281 6.66e-08 -0.375 0.312 3 75% 4 0 View 3D
ERRFI1 RCSB_PDB 0.127 3.68e-07 0.213 0.606 2 15% 13 0 View 3D