GRB2 — Abundance

🧬 View Structure

56 interactions

DMS Score Heatmap Scroll horizontally • click a column to see interactions • ■ purple strip = interface positions

SH3_GRB2_N SH2_GRB2_like SH3_GRB2_C A V I L G F Y W C M P S T N Q D E H K R * 20 40 60 80 100 120 140 160 180 200 0.24 1.00 1.50
Click a position to see interactions — ■ orange strip marks interface positions (darker = more interactions)

Significant Interactions

Interactor Predictor Log FC p-value (FDR) Cliff's Delta AUROC Unique Pos. % Unique # Interface Clashes Structure
LAT2 Predictomes -0.302 3.49e-12 -0.370 0.315 1 14% 7 0 View 3D
VAV3 Predictomes 0.123 1.58e-06 0.236 0.618 0 0% 9 0 View 3D
PTPN11 Predictomes -0.219 1.89e-11 -0.291 0.354 0 0% 11 0 View 3D
PTPN22 Predictomes 0.049 9.00e-03 0.101 0.551 — — 18 0 View 3D
VAV3 Predictomes 0.127 1.44e-10 0.266 0.633 0 0% 13 0 View 3D
TNK2 Predictomes -0.054 6.60e-01 0.023 0.512 — — 9 0 View 3D
THEMIS Predictomes 0.046 1.96e-02 0.102 0.551 7 47% 12 0 View 3D
ARHGAP9 Predictomes -0.081 5.75e-01 -0.029 0.486 1 17% 10 0 View 3D
THEMIS Predictomes 0.176 8.84e-17 0.322 0.661 7 47% 15 0 View 3D
LAT Predictomes -0.380 2.15e-19 -0.514 0.243 0 0% 6 0 View 3D
VAV3 Predictomes 0.118 4.38e-06 0.240 0.620 0 0% 8 0 View 3D
DOCK1 Predictomes -0.073 5.57e-01 -0.033 0.484 — — 8 0 View 3D
PTPN6 Predictomes -0.205 2.37e-07 -0.234 0.383 0 0% 10 0 View 3D
PTPN11 Predictomes -0.225 3.43e-12 -0.302 0.349 0 0% 11 0 View 3D
NTRK3 Predictomes 0.070 1.29e-01 0.101 0.550 2 25% 5 0 View 3D
DCTN1 Predictomes 0.255 9.69e-12 0.541 0.770 0 0% 3 0 View 3D
LRRK1 Predictomes 0.026 3.37e-01 0.053 0.527 — — 8 0 View 3D
BTK Predictomes 0.094 2.33e-03 0.217 0.609 1 25% 4 0 View 3D
ERRFI1 Predictomes 0.275 7.31e-25 0.637 0.818 0 0% 5 0 View 3D
PTPN6 Predictomes -0.201 5.68e-07 -0.227 0.387 0 0% 10 0 View 3D
LRRK1 Predictomes 0.058 2.71e-02 0.116 0.558 — — 8 0 View 3D
NTRK3 Predictomes -0.254 5.82e-12 -0.349 0.325 2 25% 8 0 View 3D
LAT2 Predictomes -0.277 2.47e-13 -0.368 0.316 1 14% 8 0 View 3D
LRRK1 Predictomes 0.039 1.67e-01 0.070 0.535 — — 9 0 View 3D
DCTN1 Predictomes 0.222 2.14e-18 0.496 0.748 0 0% 6 0 View 3D
DLGAP1 Predictomes 0.228 5.49e-16 0.503 0.752 0 0% 5 0 View 3D
PAK1 Predictomes -0.058 6.29e-01 -0.020 0.490 — — 18 0 View 3D
GAB2 Predictomes 0.089 1.03e-10 0.245 0.622 — — 16 0 View 3D
PTPN11 Predictomes -0.238 4.08e-12 -0.314 0.343 0 0% 10 0 View 3D
TNK2 Predictomes 0.017 4.49e-02 0.106 0.553 — — 8 0 View 3D
PTPN6 Predictomes -0.201 4.92e-07 -0.228 0.386 0 0% 10 0 View 3D
ARHGAP12 Predictomes -0.038 3.63e-01 0.044 0.522 — — 11 0 View 3D
DCTN1 Predictomes 0.192 1.47e-14 0.438 0.719 0 0% 6 0 View 3D
BTK Predictomes -0.175 1.07e-05 -0.311 0.345 1 25% 4 0 View 3D
LAT2 Predictomes -0.273 1.01e-12 -0.359 0.321 1 14% 8 0 View 3D
NTRK3 Predictomes -0.295 7.40e-18 -0.419 0.291 2 25% 9 0 View 3D
ARHGAP9 Predictomes -0.060 6.23e-01 -0.023 0.489 1 17% 13 0 View 3D
THEMIS Predictomes 0.158 1.33e-13 0.287 0.643 7 47% 15 0 View 3D
ARHGAP12 Predictomes -0.006 1.83e-01 0.060 0.530 — — 13 0 View 3D
ARHGAP9 Predictomes 0.211 2.39e-17 0.485 0.743 1 17% 6 0 View 3D
PTPN22 Zhang_et_al 0.232 1.64e-23 0.530 0.765 1 14% 7 0 View 3D
REPS2 Zhang_et_al 0.205 1.36e-13 0.514 0.757 0 0% 4 0 View 3D
PAK2 Zhang_et_al 0.159 1.69e-15 0.290 0.645 0 0% 19 0 View 3D
GAB3 Zhang_et_al 0.218 5.50e-27 0.438 0.719 1 8% 13 0 View 3D
RAPGEF1 Zhang_et_al 0.208 4.85e-14 0.523 0.761 0 0% 4 0 View 3D
REPS1 Zhang_et_al 0.143 6.16e-08 0.316 0.658 1 17% 6 0 View 3D
GRB2 RCSB_PDB -0.006 1.38e-01 -0.069 0.466 2 25% 15 0 View 3D
GRB2 RCSB_PDB -0.046 4.65e-03 -0.130 0.435 2 25% 17 0 View 3D
GRB2 RCSB_PDB 0.211 4.58e-09 0.324 0.662 2 25% 8 0 View 3D
GRB2 RCSB_PDB 0.205 1.29e-07 0.291 0.646 2 25% 8 0 View 3D
GRB2 RCSB_PDB -0.164 1.25e-04 -0.227 0.386 2 25% 6 0 View 3D
GRB2 RCSB_PDB -0.161 1.50e-04 -0.225 0.388 2 25% 6 0 View 3D
GAB2 RCSB_PDB 0.115 1.18e-05 0.287 0.644 0 0% 6 0 View 3D
Vav1 RCSB_PDB 0.124 3.35e-08 0.312 0.656 0 0% 9 0 View 3D
GRB2 RCSB_PDB -0.035 1.96e-02 -0.107 0.446 2 25% 15 0 View 3D
GRB2 RCSB_PDB -0.060 4.64e-04 -0.161 0.420 2 25% 15 0 View 3D