GRB2 — Activity

🧬 View Structure

56 interactions

DMS Score Heatmap Scroll horizontally • click a column to see interactions • ■ purple strip = interface positions

SH3_GRB2_N SH2_GRB2_like SH3_GRB2_C A V I L G F Y W C M P S T N Q D E H K R * 20 40 60 80 100 120 140 160 180 200 0.50 1.00 1.57
Click a position to see interactions — ■ orange strip marks interface positions (darker = more interactions)

Significant Interactions

Interactor Predictor Log FC p-value (FDR) Cliff's Delta AUROC Unique Pos. % Unique # Interface Clashes Structure
LAT2 Predictomes -0.331 2.78e-49 -0.781 0.110 0 0% 7 0 View 3D
VAV3 Predictomes 0.122 3.90e-15 0.382 0.691 4 44% 9 0 View 3D
PTPN11 Predictomes -0.216 5.94e-38 -0.554 0.223 0 0% 11 0 View 3D
PTPN22 Predictomes -0.135 7.30e-24 -0.377 0.312 5 28% 18 0 View 3D
VAV3 Predictomes 0.059 2.63e-04 0.154 0.577 4 44% 13 0 View 3D
TNK2 Predictomes -0.136 1.61e-19 -0.431 0.284 3 33% 9 0 View 3D
THEMIS Predictomes 0.105 5.00e-12 0.291 0.645 7 58% 12 0 View 3D
ARHGAP9 Predictomes -0.177 2.19e-24 -0.471 0.265 0 0% 10 0 View 3D
THEMIS Predictomes 0.112 2.18e-14 0.296 0.648 7 58% 15 0 View 3D
LAT Predictomes -0.285 1.01e-37 -0.731 0.135 0 0% 6 0 View 3D
VAV3 Predictomes 0.117 3.43e-12 0.361 0.680 4 44% 8 0 View 3D
DOCK1 Predictomes -0.104 6.69e-07 -0.252 0.374 0 0% 8 0 View 3D
PTPN6 Predictomes -0.255 6.00e-42 -0.607 0.197 0 0% 10 0 View 3D
PTPN11 Predictomes -0.216 2.45e-37 -0.551 0.225 0 0% 11 0 View 3D
NTRK3 Predictomes -0.095 1.49e-03 -0.204 0.398 2 25% 5 0 View 3D
DCTN1 Predictomes -0.164 2.81e-13 -0.579 0.211 0 0% 3 0 View 3D
LRRK1 Predictomes 0.006 8.68e-01 0.010 0.505 — — 8 0 View 3D
BTK Predictomes 0.024 9.09e-02 0.124 0.562 1 25% 4 0 View 3D
ERRFI1 Predictomes -0.018 3.66e-01 -0.061 0.470 — — 5 0 View 3D
PTPN6 Predictomes -0.254 6.74e-42 -0.607 0.197 0 0% 10 0 View 3D
LRRK1 Predictomes 0.034 1.59e-01 0.075 0.538 — — 8 0 View 3D
NTRK3 Predictomes -0.180 2.71e-20 -0.466 0.267 2 25% 8 0 View 3D
LAT2 Predictomes -0.317 9.15e-53 -0.765 0.118 0 0% 8 0 View 3D
LRRK1 Predictomes 0.040 4.10e-02 0.102 0.551 — — 9 0 View 3D
DCTN1 Predictomes -0.065 2.16e-04 -0.214 0.393 0 0% 6 0 View 3D
DLGAP1 Predictomes -0.092 2.93e-03 -0.190 0.405 — — 5 0 View 3D
PAK1 Predictomes -0.078 1.63e-08 -0.206 0.397 — — 18 0 View 3D
GAB2 Predictomes -0.041 1.46e-02 -0.095 0.452 — — 16 0 View 3D
PTPN11 Predictomes -0.241 7.43e-43 -0.617 0.192 0 0% 10 0 View 3D
TNK2 Predictomes -0.169 1.19e-19 -0.458 0.271 3 33% 8 0 View 3D
PTPN6 Predictomes -0.253 1.32e-41 -0.604 0.198 0 0% 10 0 View 3D
ARHGAP12 Predictomes -0.169 1.10e-23 -0.444 0.278 0 0% 11 0 View 3D
DCTN1 Predictomes -0.055 6.69e-04 -0.198 0.401 0 0% 6 0 View 3D
BTK Predictomes -0.267 1.46e-17 -0.594 0.203 1 25% 4 0 View 3D
LAT2 Predictomes -0.316 1.21e-52 -0.764 0.118 0 0% 8 0 View 3D
NTRK3 Predictomes -0.165 7.85e-15 -0.379 0.311 2 25% 9 0 View 3D
ARHGAP9 Predictomes -0.127 8.87e-17 -0.343 0.328 0 0% 13 0 View 3D
THEMIS Predictomes 0.122 5.40e-19 0.344 0.672 7 58% 15 0 View 3D
ARHGAP12 Predictomes -0.132 4.17e-20 -0.386 0.307 0 0% 13 0 View 3D
ARHGAP9 Predictomes -0.022 4.44e-01 -0.048 0.476 0 0% 6 0 View 3D
PTPN22 Zhang_et_al -0.019 1.36e-01 -0.088 0.456 — — 7 0 View 3D
REPS2 Zhang_et_al 0.001 8.30e-01 0.019 0.509 — — 4 0 View 3D
PAK2 Zhang_et_al -0.001 8.67e-01 0.008 0.504 — — 19 0 View 3D
GAB3 Zhang_et_al 0.108 6.00e-12 0.282 0.641 1 8% 13 0 View 3D
RAPGEF1 Zhang_et_al 0.003 7.43e-01 0.029 0.515 — — 4 0 View 3D
REPS1 Zhang_et_al -0.023 2.64e-01 -0.073 0.464 — — 6 0 View 3D
GRB2 RCSB_PDB 0.092 7.25e-11 0.286 0.643 3 38% 15 0 View 3D
GRB2 RCSB_PDB 0.079 5.08e-07 0.227 0.614 3 38% 17 0 View 3D
GRB2 RCSB_PDB -0.167 4.63e-13 -0.397 0.301 3 38% 8 0 View 3D
GRB2 RCSB_PDB -0.088 3.44e-04 -0.199 0.400 3 38% 8 0 View 3D
GRB2 RCSB_PDB 0.087 9.44e-06 0.262 0.631 3 38% 6 0 View 3D
GRB2 RCSB_PDB 0.090 3.13e-06 0.275 0.638 3 38% 6 0 View 3D
GAB2 RCSB_PDB 0.175 1.35e-18 0.567 0.783 0 0% 6 0 View 3D
Vav1 RCSB_PDB 0.091 1.16e-06 0.276 0.638 — — 9 0 View 3D
GRB2 RCSB_PDB 0.099 2.76e-11 0.294 0.647 3 38% 15 0 View 3D
GRB2 RCSB_PDB 0.120 2.48e-15 0.356 0.678 3 38% 15 0 View 3D