MAP2K1 — Abundance

🧬 View Structure

79 interactions

DMS Score Heatmap Scroll horizontally • click a column to see interactions • ■ purple strip = interface positions

PKc_MAP2K1 A V I L G F Y W C M P S T N Q D E H K R * 20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 0.09 1.00 1.50
Click a position to see interactions — ■ orange strip marks interface positions (darker = more interactions)

Significant Interactions

Interactor Predictor Log FC p-value (FDR) Cliff's Delta AUROC Unique Pos. % Unique # Interface Clashes Structure
ARAF Predictomes 0.001 6.72e-01 0.020 0.510 — — 12 0 View 3D
MAP3K1 Predictomes -0.021 2.28e-01 -0.059 0.471 — — 10 0 View 3D
KSR2 Predictomes 0.007 4.03e-01 0.035 0.518 — — 14 0 View 3D
WNK1 Predictomes -0.032 2.08e-01 -0.077 0.462 — — 6 0 View 3D
MAP3K8 Predictomes 0.000 8.04e-01 0.013 0.506 — — 10 0 View 3D
KSR1 Predictomes 0.010 2.41e-01 0.045 0.523 — — 17 0 View 3D
RAF1 Predictomes 0.007 6.29e-01 0.020 0.510 — — 15 0 View 3D
MAP3K8 Predictomes 0.006 6.32e-01 0.030 0.515 — — 6 0 View 3D
MAP2K6 Predictomes -0.010 7.17e-01 -0.028 0.486 — — 4 0 View 3D
WNK1 Predictomes -0.037 1.00e-01 -0.078 0.461 — — 10 0 View 3D
KSR1 Predictomes 0.010 2.71e-01 0.043 0.522 — — 16 0 View 3D
MAP2K2 Predictomes -0.009 6.17e-01 -0.023 0.488 — — 12 0 View 3D
MAPK3 Predictomes 0.009 2.58e-01 0.052 0.526 — — 12 0 View 3D
MAP3K4 Predictomes -0.013 6.52e-01 -0.025 0.487 — — 8 0 View 3D
MAP3K8 Predictomes 0.003 6.31e-01 0.025 0.513 — — 9 0 View 3D
MAPK3 Predictomes 0.016 1.42e-01 0.067 0.534 — — 12 0 View 3D
STK11 Predictomes -0.012 7.81e-01 -0.017 0.492 — — 7 0 View 3D
MAP2K2 Predictomes -0.013 4.84e-01 -0.037 0.482 — — 9 0 View 3D
RAF1 Predictomes 0.000 8.31e-01 0.011 0.505 — — 11 0 View 3D
MAPK1 Predictomes -0.008 9.10e-01 -0.005 0.497 — — 12 0 View 3D
ARAF Predictomes 0.006 5.27e-01 0.027 0.514 — — 14 0 View 3D
MAP3K1 Predictomes -0.020 4.75e-01 -0.040 0.480 — — 8 0 View 3D
BRAF Predictomes 0.005 4.44e-01 0.035 0.517 — — 12 0 View 3D
KSR1 Predictomes 0.010 2.95e-01 0.041 0.521 — — 16 0 View 3D
MAP3K1 Predictomes -0.023 2.87e-01 -0.058 0.471 — — 8 0 View 3D
MAPK1 Predictomes 0.016 1.35e-01 0.071 0.535 — — 11 0 View 3D
KSR2 Predictomes 0.007 4.16e-01 0.034 0.517 — — 14 0 View 3D
STK11 Predictomes -0.016 4.89e-01 -0.041 0.480 — — 7 0 View 3D
MAP3K4 Predictomes -0.006 9.56e-01 0.003 0.502 — — 7 0 View 3D
WDR83 Predictomes -0.030 3.93e-01 -0.044 0.478 — — 9 0 View 3D
WDR83 Predictomes -0.024 5.34e-01 -0.030 0.485 — — 11 0 View 3D
BRAF Predictomes 0.007 5.14e-01 0.031 0.516 — — 11 0 View 3D
WNK1 Predictomes -0.023 4.78e-01 -0.049 0.475 — — 5 0 View 3D
MAP3K7 Predictomes 0.015 1.57e-01 0.053 0.527 — — 18 0 View 3D
MAP3K7 Predictomes 0.012 3.34e-01 0.037 0.519 — — 17 0 View 3D
MAP3K7 Predictomes 0.007 5.73e-01 0.024 0.512 — — 15 0 View 3D
MAP2K6 Predictomes -0.021 2.67e-01 -0.060 0.470 — — 8 0 View 3D
ARAF Predictomes 0.007 5.70e-01 0.024 0.512 — — 15 0 View 3D
KSR2 Predictomes 0.004 5.33e-01 0.027 0.513 — — 14 0 View 3D
MAP2K2 Predictomes -0.009 5.95e-01 -0.020 0.490 — — 19 0 View 3D
MAP3K4 Predictomes -0.010 8.55e-01 -0.010 0.495 — — 8 0 View 3D
MAPK1 Predictomes -0.011 6.99e-01 -0.018 0.491 — — 12 0 View 3D
MAPK3 Predictomes 0.007 3.68e-01 0.042 0.521 — — 12 0 View 3D
MAP2K6 Predictomes -0.022 6.12e-01 -0.035 0.482 — — 5 0 View 3D
STK11 Predictomes -0.016 5.16e-01 -0.038 0.481 — — 7 0 View 3D
WDR83 Predictomes -0.020 6.84e-01 -0.020 0.490 — — 11 0 View 3D
BRAF Predictomes 0.004 5.22e-01 0.029 0.515 — — 12 0 View 3D
RAF1 Predictomes 0.009 4.09e-01 0.037 0.519 — — 12 0 View 3D
MAPK3 Zhang_et_al -0.026 9.13e-01 -0.008 0.496 — — 6 0 View 3D
MAP3K2 Zhang_et_al -0.021 2.29e-01 -0.055 0.473 — — 13 0 View 3D
BRAF Zhang_et_al -0.015 4.55e-01 -0.041 0.479 — — 10 0 View 3D
MAP3K1 Zhang_et_al -0.024 1.35e-01 -0.073 0.463 — — 11 0 View 3D
PEBP4 Zhang_et_al -0.040 3.72e-02 -0.142 0.429 — — 5 0 View 3D
MAP3K8 Zhang_et_al -0.033 1.80e-01 -0.081 0.459 — — 7 0 View 3D
MAPK1 Zhang_et_al -0.027 5.69e-01 -0.038 0.481 — — 7 0 View 3D
MAP3K3 Zhang_et_al -0.008 8.30e-01 -0.012 0.494 — — 10 0 View 3D
PLEKHF2 Zhang_et_al 0.012 8.80e-01 0.015 0.508 — — 3 0 View 3D
ARAF Zhang_et_al -0.005 9.92e-01 -0.001 0.500 — — 8 0 View 3D
GRK2 Zhang_et_al -0.027 8.91e-01 -0.012 0.494 — — 4 0 View 3D
TRIB1 Zhang_et_al -0.000 8.73e-01 0.013 0.506 — — 5 0 View 3D
RAF1 Zhang_et_al 0.008 6.26e-01 0.028 0.514 — — 10 0 View 3D
MAP2K1 RCSB_PDB -0.009 5.37e-01 -0.029 0.486 — — 12 0 View 3D
MAP2K1 RCSB_PDB -0.003 8.55e-01 -0.008 0.496 — — 14 0 View 3D
MAP2K1 RCSB_PDB -0.007 5.96e-01 -0.025 0.488 — — 12 0 View 3D
MAP2K1 RCSB_PDB -0.004 8.28e-01 -0.010 0.495 — — 14 0 View 3D
BRAF RCSB_PDB 0.012 2.49e-01 0.049 0.525 — — 13 0 View 3D
RAF1 RCSB_PDB 0.009 3.62e-01 0.038 0.519 — — 15 0 View 3D
BRAF RCSB_PDB 0.015 1.54e-01 0.053 0.527 — — 18 0 View 3D
MAP2K1 RCSB_PDB -0.012 8.37e-01 0.012 0.506 — — 9 0 View 3D
MAP2K1 RCSB_PDB -0.019 8.71e-01 -0.008 0.496 — — 10 0 View 3D
MAP2K1 RCSB_PDB 0.009 7.49e-01 0.021 0.511 — — 6 0 View 3D
MAP2K1 RCSB_PDB 0.011 5.05e-01 0.047 0.523 — — 5 0 View 3D
BRAF RCSB_PDB 0.012 3.01e-01 0.042 0.521 — — 15 0 View 3D
MAP2K1 RCSB_PDB -0.014 3.27e-01 -0.046 0.477 — — 11 0 View 3D
MAP2K1 RCSB_PDB -0.008 5.93e-01 -0.024 0.488 — — 13 0 View 3D
RAF1 RCSB_PDB 0.008 4.22e-01 0.033 0.517 — — 15 0 View 3D
14-3-3zeta RCSB_PDB -0.028 4.85e-01 -0.053 0.473 — — 4 0 View 3D
RAF1 RCSB_PDB 0.023 5.91e-02 0.073 0.537 — — 16 0 View 3D
BRAF RCSB_PDB 0.015 1.49e-01 0.054 0.527 — — 18 0 View 3D