MAP2K1 — Abundance_hsp90i

🧬 View Structure

79 interactions

DMS Score Heatmap Scroll horizontally • click a column to see interactions • ■ purple strip = interface positions

PKc_MAP2K1 A V I L G F Y W C M P S T N Q D E H K R * 20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 0.06 1.00 1.50
Click a position to see interactions — ■ orange strip marks interface positions (darker = more interactions)

Significant Interactions

Interactor Predictor Log FC p-value (FDR) Cliff's Delta AUROC Unique Pos. % Unique # Interface Clashes Structure
ARAF Predictomes 0.036 1.52e-01 0.065 0.532 — — 12 0 View 3D
MAP3K1 Predictomes 0.019 6.61e-01 0.023 0.511 — — 10 0 View 3D
KSR2 Predictomes 0.027 2.41e-01 0.049 0.525 — — 14 0 View 3D
WNK1 Predictomes 0.030 5.97e-01 0.034 0.517 — — 6 0 View 3D
MAP3K8 Predictomes 0.033 3.17e-01 0.050 0.525 — — 10 0 View 3D
KSR1 Predictomes 0.038 3.21e-02 0.082 0.541 — — 17 0 View 3D
RAF1 Predictomes 0.028 3.87e-01 0.036 0.518 — — 15 0 View 3D
MAP3K8 Predictomes 0.055 3.71e-02 0.126 0.563 — — 6 0 View 3D
MAP2K6 Predictomes 0.014 6.30e-01 -0.038 0.481 — — 4 0 View 3D
WNK1 Predictomes 0.008 9.62e-01 0.003 0.501 — — 10 0 View 3D
KSR1 Predictomes 0.037 4.70e-02 0.078 0.539 — — 16 0 View 3D
MAP2K2 Predictomes 0.021 8.04e-01 0.012 0.506 — — 12 0 View 3D
MAPK3 Predictomes 0.042 3.33e-03 0.132 0.566 — — 12 0 View 3D
MAP3K4 Predictomes 0.031 4.14e-01 0.045 0.523 — — 8 0 View 3D
MAP3K8 Predictomes 0.039 1.56e-01 0.072 0.536 — — 9 0 View 3D
MAPK3 Predictomes 0.054 2.88e-04 0.164 0.582 — — 12 0 View 3D
STK11 Predictomes 0.019 9.70e-01 0.002 0.501 — — 7 0 View 3D
MAP2K2 Predictomes 0.023 7.75e-01 0.016 0.508 — — 9 0 View 3D
RAF1 Predictomes 0.033 2.80e-01 0.051 0.526 — — 11 0 View 3D
MAPK1 Predictomes 0.042 7.22e-03 0.121 0.561 — — 12 0 View 3D
ARAF Predictomes 0.034 1.64e-01 0.059 0.529 — — 14 0 View 3D
MAP3K1 Predictomes 0.020 8.47e-01 0.011 0.506 — — 8 0 View 3D
BRAF Predictomes 0.039 8.13e-02 0.077 0.539 — — 12 0 View 3D
KSR1 Predictomes 0.040 2.70e-02 0.086 0.543 — — 16 0 View 3D
MAP3K1 Predictomes 0.023 7.75e-01 0.017 0.508 — — 8 0 View 3D
MAPK1 Predictomes 0.055 1.61e-04 0.177 0.589 — — 11 0 View 3D
KSR2 Predictomes 0.030 1.67e-01 0.058 0.529 — — 14 0 View 3D
STK11 Predictomes 0.026 6.51e-01 0.027 0.514 — — 7 0 View 3D
MAP3K4 Predictomes 0.020 8.77e-01 0.010 0.505 — — 7 0 View 3D
WDR83 Predictomes 0.022 2.66e-01 0.057 0.529 — — 9 0 View 3D
WDR83 Predictomes 0.016 4.97e-01 0.033 0.516 — — 11 0 View 3D
BRAF Predictomes 0.038 1.17e-01 0.073 0.537 — — 11 0 View 3D
WNK1 Predictomes 0.037 4.87e-01 0.049 0.524 — — 5 0 View 3D
MAP3K7 Predictomes 0.038 4.19e-02 0.077 0.538 — — 18 0 View 3D
MAP3K7 Predictomes 0.023 3.34e-01 0.038 0.519 — — 17 0 View 3D
MAP3K7 Predictomes 0.038 5.58e-02 0.078 0.539 — — 15 0 View 3D
MAP2K6 Predictomes 0.024 8.36e-01 0.012 0.506 — — 8 0 View 3D
ARAF Predictomes 0.028 3.28e-01 0.041 0.520 — — 15 0 View 3D
KSR2 Predictomes 0.028 2.06e-01 0.053 0.527 — — 14 0 View 3D
MAP2K2 Predictomes 0.005 8.50e-01 -0.008 0.496 — — 19 0 View 3D
MAP3K4 Predictomes 0.013 8.57e-01 -0.010 0.495 — — 8 0 View 3D
MAPK1 Predictomes 0.036 2.48e-02 0.101 0.551 — — 12 0 View 3D
MAPK3 Predictomes 0.039 1.13e-02 0.116 0.558 — — 12 0 View 3D
MAP2K6 Predictomes 0.019 9.20e-01 -0.007 0.496 — — 5 0 View 3D
STK11 Predictomes 0.023 7.42e-01 0.020 0.510 — — 7 0 View 3D
WDR83 Predictomes 0.017 4.94e-01 0.033 0.516 — — 11 0 View 3D
BRAF Predictomes 0.035 1.43e-01 0.066 0.533 — — 12 0 View 3D
RAF1 Predictomes 0.034 1.76e-01 0.061 0.531 — — 12 0 View 3D
MAPK3 Zhang_et_al 0.016 2.73e-01 0.074 0.537 — — 6 0 View 3D
MAP3K2 Zhang_et_al 0.007 6.15e-01 -0.026 0.487 — — 13 0 View 3D
BRAF Zhang_et_al 0.039 3.09e-01 0.054 0.527 — — 10 0 View 3D
MAP3K1 Zhang_et_al 0.013 8.02e-01 -0.015 0.493 — — 11 0 View 3D
PEBP4 Zhang_et_al 0.007 7.94e-01 0.022 0.511 — — 5 0 View 3D
MAP3K8 Zhang_et_al 0.016 8.62e-01 -0.012 0.494 — — 7 0 View 3D
MAPK1 Zhang_et_al 0.018 1.57e-01 0.087 0.543 — — 7 0 View 3D
MAP3K3 Zhang_et_al 0.034 2.62e-01 0.059 0.530 — — 10 0 View 3D
PLEKHF2 Zhang_et_al -0.002 8.11e-01 -0.025 0.487 — — 3 0 View 3D
ARAF Zhang_et_al 0.022 5.69e-01 0.036 0.518 — — 8 0 View 3D
GRK2 Zhang_et_al -0.007 6.55e-01 0.040 0.520 — — 4 0 View 3D
TRIB1 Zhang_et_al 0.048 3.75e-02 0.141 0.570 — — 5 0 View 3D
RAF1 Zhang_et_al 0.032 2.76e-01 0.058 0.529 — — 10 0 View 3D
MAP2K1 RCSB_PDB 0.033 2.93e-01 0.048 0.524 6 100% 12 0 View 3D
MAP2K1 RCSB_PDB 0.038 7.83e-02 0.074 0.537 6 100% 14 0 View 3D
MAP2K1 RCSB_PDB 0.035 2.32e-01 0.054 0.527 6 100% 12 0 View 3D
MAP2K1 RCSB_PDB 0.037 1.11e-01 0.068 0.534 6 100% 14 0 View 3D
BRAF RCSB_PDB 0.034 1.09e-01 0.070 0.535 — — 13 0 View 3D
RAF1 RCSB_PDB 0.046 4.76e-02 0.081 0.540 — — 15 0 View 3D
BRAF RCSB_PDB 0.035 5.15e-02 0.073 0.537 — — 18 0 View 3D
MAP2K1 RCSB_PDB 0.023 1.95e-01 0.067 0.534 6 100% 9 0 View 3D
MAP2K1 RCSB_PDB 0.033 6.13e-02 0.092 0.546 6 100% 10 0 View 3D
MAP2K1 RCSB_PDB -0.135 3.59e-06 -0.267 0.366 6 100% 6 0 View 3D
MAP2K1 RCSB_PDB -0.063 2.97e-02 -0.148 0.426 6 100% 5 0 View 3D
BRAF RCSB_PDB 0.032 1.75e-01 0.056 0.528 — — 15 0 View 3D
MAP2K1 RCSB_PDB 0.031 3.89e-01 0.041 0.521 6 100% 11 0 View 3D
MAP2K1 RCSB_PDB 0.037 1.35e-01 0.066 0.533 6 100% 13 0 View 3D
RAF1 RCSB_PDB 0.045 5.14e-02 0.079 0.539 — — 15 0 View 3D
14-3-3zeta RCSB_PDB 0.003 3.63e-01 -0.071 0.465 — — 4 0 View 3D
RAF1 RCSB_PDB 0.067 8.28e-04 0.127 0.563 — — 16 0 View 3D
BRAF RCSB_PDB 0.036 4.43e-02 0.076 0.538 — — 18 0 View 3D