MAP2K1 — Activity

🧬 View Structure

79 interactions

DMS Score Heatmap Scroll horizontally • click a column to see interactions • ■ purple strip = interface positions

PKc_MAP2K1 A V I L G F Y W C M P S T N Q D E H K R * 20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 0.50 1.00 2.50
Click a position to see interactions — ■ orange strip marks interface positions (darker = more interactions)

Significant Interactions

Interactor Predictor Log FC p-value (FDR) Cliff's Delta AUROC Unique Pos. % Unique # Interface Clashes Structure
ARAF Predictomes -0.114 1.79e-05 -0.183 0.408 0 0% 12 0 View 3D
MAP3K1 Predictomes 0.203 3.24e-01 0.049 0.524 — — 10 0 View 3D
KSR2 Predictomes -0.139 8.84e-06 -0.175 0.413 0 0% 14 0 View 3D
WNK1 Predictomes -0.038 4.17e-01 -0.051 0.475 — — 6 0 View 3D
MAP3K8 Predictomes -0.070 1.29e-02 -0.117 0.442 — — 10 0 View 3D
KSR1 Predictomes -0.091 8.02e-04 -0.124 0.438 0 0% 17 0 View 3D
RAF1 Predictomes -0.051 4.79e-02 -0.079 0.460 0 0% 15 0 View 3D
MAP3K8 Predictomes -0.079 1.07e-01 -0.097 0.451 — — 6 0 View 3D
MAP2K6 Predictomes -0.019 2.48e-01 -0.087 0.457 — — 4 0 View 3D
WNK1 Predictomes -0.014 6.03e-01 -0.026 0.487 — — 10 0 View 3D
KSR1 Predictomes -0.131 5.55e-07 -0.187 0.406 0 0% 16 0 View 3D
MAP2K2 Predictomes 0.179 1.62e-07 0.222 0.611 4 33% 12 0 View 3D
MAPK3 Predictomes 0.013 8.02e-02 0.079 0.539 — — 12 0 View 3D
MAP3K4 Predictomes -0.033 5.11e-01 -0.037 0.482 — — 8 0 View 3D
MAP3K8 Predictomes -0.088 3.26e-03 -0.143 0.428 — — 9 0 View 3D
MAPK3 Predictomes 0.061 7.51e-06 0.196 0.598 — — 12 0 View 3D
STK11 Predictomes -0.040 4.73e-01 -0.042 0.479 — — 7 0 View 3D
MAP2K2 Predictomes 0.071 1.45e-02 0.121 0.560 4 33% 9 0 View 3D
RAF1 Predictomes -0.114 3.30e-05 -0.185 0.407 0 0% 11 0 View 3D
MAPK1 Predictomes 0.049 5.93e-06 0.192 0.596 — — 12 0 View 3D
ARAF Predictomes -0.089 1.07e-03 -0.132 0.434 0 0% 14 0 View 3D
MAP3K1 Predictomes -0.093 1.08e-03 -0.169 0.415 — — 8 0 View 3D
BRAF Predictomes -0.116 6.51e-06 -0.190 0.405 0 0% 12 0 View 3D
KSR1 Predictomes -0.127 1.30e-06 -0.182 0.409 0 0% 16 0 View 3D
MAP3K1 Predictomes 0.000 9.92e-01 0.001 0.500 — — 8 0 View 3D
MAPK1 Predictomes -0.051 9.92e-01 -0.001 0.500 — — 11 0 View 3D
KSR2 Predictomes -0.121 1.95e-05 -0.169 0.416 0 0% 14 0 View 3D
STK11 Predictomes 0.010 1.83e-01 0.076 0.538 — — 7 0 View 3D
MAP3K4 Predictomes -0.063 2.99e-02 -0.122 0.439 — — 7 0 View 3D
WDR83 Predictomes -0.011 2.67e-01 0.056 0.528 — — 9 0 View 3D
WDR83 Predictomes -0.081 3.06e-01 -0.048 0.476 — — 11 0 View 3D
BRAF Predictomes -0.065 3.69e-03 -0.130 0.435 0 0% 11 0 View 3D
WNK1 Predictomes -0.046 5.95e-01 -0.037 0.481 — — 5 0 View 3D
MAP3K7 Predictomes -0.027 8.37e-02 -0.065 0.468 — — 18 0 View 3D
MAP3K7 Predictomes -0.003 8.08e-01 -0.010 0.495 — — 17 0 View 3D
MAP3K7 Predictomes 0.028 2.30e-01 0.049 0.525 — — 15 0 View 3D
MAP2K6 Predictomes 0.026 3.23e-01 0.054 0.527 — — 8 0 View 3D
ARAF Predictomes -0.052 3.61e-02 -0.083 0.458 0 0% 15 0 View 3D
KSR2 Predictomes -0.105 4.85e-05 -0.161 0.420 0 0% 14 0 View 3D
MAP2K2 Predictomes 0.117 3.21e-06 0.163 0.581 4 33% 19 0 View 3D
MAP3K4 Predictomes -0.028 1.73e-01 -0.073 0.463 — — 8 0 View 3D
MAPK1 Predictomes 0.099 6.72e-10 0.261 0.631 — — 12 0 View 3D
MAPK3 Predictomes 0.037 5.87e-05 0.174 0.587 — — 12 0 View 3D
MAP2K6 Predictomes -0.088 5.11e-03 -0.181 0.410 — — 5 0 View 3D
STK11 Predictomes 0.008 1.85e-01 0.076 0.538 — — 7 0 View 3D
WDR83 Predictomes -0.085 2.08e-01 -0.058 0.471 — — 11 0 View 3D
BRAF Predictomes -0.130 2.63e-07 -0.217 0.391 0 0% 12 0 View 3D
RAF1 Predictomes -0.133 1.83e-06 -0.203 0.399 0 0% 12 0 View 3D
MAPK3 Zhang_et_al 0.007 9.00e-02 0.108 0.554 — — 6 0 View 3D
MAP3K2 Zhang_et_al 0.029 2.46e-01 0.053 0.527 — — 13 0 View 3D
BRAF Zhang_et_al 0.024 9.12e-01 -0.006 0.497 — — 10 0 View 3D
MAP3K1 Zhang_et_al 0.097 8.81e-05 0.178 0.589 — — 11 0 View 3D
PEBP4 Zhang_et_al -0.164 2.05e-03 -0.206 0.397 — — 5 0 View 3D
MAP3K8 Zhang_et_al 0.029 1.34e-01 0.091 0.545 — — 7 0 View 3D
MAPK1 Zhang_et_al 0.087 8.86e-08 0.289 0.645 — — 7 0 View 3D
MAP3K3 Zhang_et_al -0.046 1.25e-01 -0.078 0.461 — — 10 0 View 3D
PLEKHF2 Zhang_et_al 0.189 7.30e-07 0.406 0.703 1 33% 3 0 View 3D
ARAF Zhang_et_al -0.070 2.18e-01 -0.071 0.465 — — 8 0 View 3D
GRK2 Zhang_et_al 0.041 6.46e-01 0.040 0.520 — — 4 0 View 3D
TRIB1 Zhang_et_al 0.026 1.19e-02 0.169 0.584 — — 5 0 View 3D
RAF1 Zhang_et_al -0.077 1.94e-03 -0.149 0.426 — — 10 0 View 3D
MAP2K1 RCSB_PDB 0.078 6.81e-06 0.193 0.597 — — 12 0 View 3D
MAP2K1 RCSB_PDB 0.084 3.42e-08 0.220 0.610 — — 14 0 View 3D
MAP2K1 RCSB_PDB 0.086 5.76e-06 0.195 0.597 — — 12 0 View 3D
MAP2K1 RCSB_PDB 0.082 2.40e-08 0.223 0.611 — — 14 0 View 3D
BRAF RCSB_PDB -0.088 5.80e-05 -0.164 0.418 — — 13 0 View 3D
RAF1 RCSB_PDB -0.178 5.02e-05 -0.157 0.421 0 0% 15 0 View 3D
BRAF RCSB_PDB -0.076 3.03e-05 -0.149 0.425 — — 18 0 View 3D
MAP2K1 RCSB_PDB 0.047 4.64e-04 0.170 0.585 — — 9 0 View 3D
MAP2K1 RCSB_PDB 0.033 5.74e-04 0.159 0.580 — — 10 0 View 3D
MAP2K1 RCSB_PDB -0.101 1.51e-01 0.086 0.543 — — 6 0 View 3D
MAP2K1 RCSB_PDB -0.052 2.31e-01 0.083 0.542 — — 5 0 View 3D
BRAF RCSB_PDB -0.088 1.95e-06 -0.183 0.408 — — 15 0 View 3D
MAP2K1 RCSB_PDB 0.076 8.05e-05 0.176 0.588 — — 11 0 View 3D
MAP2K1 RCSB_PDB 0.086 7.29e-07 0.205 0.602 — — 13 0 View 3D
RAF1 RCSB_PDB -0.195 6.54e-06 -0.174 0.413 0 0% 15 0 View 3D
14-3-3zeta RCSB_PDB -0.137 1.00e-01 -0.123 0.439 — — 4 0 View 3D
RAF1 RCSB_PDB -0.220 3.70e-09 -0.219 0.391 0 0% 16 0 View 3D
BRAF RCSB_PDB -0.080 1.17e-05 -0.157 0.421 — — 18 0 View 3D