MAP2K2 — Abundance_hsp90i

🧬 View Structure

59 interactions

DMS Score Heatmap Scroll horizontally • click a column to see interactions • ■ purple strip = interface positions

PKc_MAP2K2 A V I L G F Y W C M P S T N Q D E H K R * 20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 0.07 1.00 1.50
Click a position to see interactions — ■ orange strip marks interface positions (darker = more interactions)

Significant Interactions

Interactor Predictor Log FC p-value (FDR) Cliff's Delta AUROC Unique Pos. % Unique # Interface Clashes Structure
KSR2 Predictomes 0.207 2.58e-11 0.252 0.626 0 0% 15 0 View 3D
MAP4K5 Predictomes 0.167 1.49e-03 0.155 0.578 4 40% 9 0 View 3D
MAP3K7 Predictomes 0.238 1.40e-14 0.272 0.636 0 0% 18 0 View 3D
MAPK1 Predictomes 0.214 7.03e-12 0.279 0.639 0 0% 13 0 View 3D
BRAF Predictomes 0.221 9.62e-10 0.248 0.624 0 0% 13 0 View 3D
MAPK3 Predictomes 0.237 1.17e-15 0.325 0.663 1 8% 13 0 View 3D
KSR2 Predictomes 0.215 1.63e-11 0.262 0.631 0 0% 14 0 View 3D
WDR83 Predictomes 0.112 1.31e-02 0.110 0.555 — — 11 0 View 3D
ARAF Predictomes 0.200 1.53e-09 0.229 0.615 0 0% 15 0 View 3D
ARAF Predictomes 0.204 6.72e-08 0.226 0.613 0 0% 12 0 View 3D
MAP2K1 Predictomes 0.099 3.80e-02 0.090 0.545 0 0% 12 0 View 3D
STK26 Predictomes 0.237 4.76e-11 0.286 0.643 0 0% 11 0 View 3D
MAPK8 Predictomes 0.225 9.88e-07 0.247 0.624 2 25% 8 0 View 3D
MAP2K1 Predictomes 0.183 4.80e-05 0.195 0.597 0 0% 9 0 View 3D
RAF1 Predictomes 0.240 1.06e-14 0.292 0.646 0 0% 15 0 View 3D
STK26 Predictomes 0.239 2.93e-16 0.299 0.650 0 0% 16 0 View 3D
MAP3K7 Predictomes 0.213 8.54e-10 0.235 0.617 0 0% 15 0 View 3D
MAP2K5 Predictomes 0.263 4.37e-05 0.331 0.666 2 67% 3 0 View 3D
MAP2K3 Predictomes 0.140 3.63e-02 0.125 0.562 — — 6 0 View 3D
ARAF Predictomes 0.211 2.48e-10 0.240 0.620 0 0% 15 0 View 3D
RAF1 Predictomes 0.214 4.27e-11 0.243 0.622 0 0% 16 0 View 3D
MAP2K3 Predictomes 0.167 1.78e-03 0.160 0.580 — — 8 0 View 3D
MAP4K5 Predictomes 0.127 3.71e-02 0.092 0.546 4 40% 12 0 View 3D
STK26 Predictomes 0.195 2.11e-05 0.217 0.609 0 0% 8 0 View 3D
RAF1 Predictomes 0.198 9.33e-09 0.224 0.612 0 0% 14 0 View 3D
WDR83 Predictomes 0.134 3.80e-03 0.128 0.564 — — 11 0 View 3D
MAP2K5 Predictomes 0.277 1.52e-05 0.350 0.675 2 67% 3 0 View 3D
KSR1 Predictomes 0.128 5.49e-04 0.127 0.564 6 35% 17 0 View 3D
WDR83 Predictomes 0.094 1.48e-01 0.069 0.535 — — 10 0 View 3D
MAP4K5 Predictomes 0.213 3.98e-06 0.213 0.606 4 40% 10 0 View 3D
MOS Predictomes 0.203 1.33e-07 0.230 0.615 0 0% 11 0 View 3D
MAPK3 Predictomes 0.203 6.25e-08 0.261 0.631 1 8% 9 0 View 3D
KSR1 Predictomes 0.225 3.01e-14 0.272 0.636 6 35% 17 0 View 3D
MOS Predictomes 0.160 1.08e-04 0.171 0.586 0 0% 11 0 View 3D
MOS Predictomes 0.189 1.19e-06 0.213 0.606 0 0% 11 0 View 3D
BRAF Predictomes 0.236 1.27e-11 0.273 0.636 0 0% 13 0 View 3D
MAPK1 Predictomes 0.203 9.01e-09 0.252 0.626 0 0% 11 0 View 3D
MAP2K1 Predictomes 0.088 2.54e-03 0.102 0.551 0 0% 21 0 View 3D
MAP3K7 Predictomes 0.231 9.12e-16 0.276 0.638 0 0% 19 0 View 3D
BRAF Predictomes 0.235 6.48e-11 0.262 0.631 0 0% 13 0 View 3D
MAPK3 Predictomes 0.191 5.31e-08 0.239 0.619 1 8% 11 0 View 3D
MAPK1 Predictomes 0.190 4.00e-08 0.252 0.626 0 0% 10 0 View 3D
KSR2 Predictomes 0.213 1.18e-11 0.255 0.628 0 0% 15 0 View 3D
MAP2K3 Predictomes 0.132 1.94e-02 0.129 0.564 — — 7 0 View 3D
KSR1 Predictomes 0.235 8.85e-14 0.274 0.637 6 35% 16 0 View 3D
BRAF Zhang_et_al 0.188 1.20e-04 0.174 0.587 0 0% 11 0 View 3D
MAPK1 Zhang_et_al 0.185 3.90e-04 0.213 0.606 0 0% 6 0 View 3D
RHOBTB2 Zhang_et_al 0.240 1.69e-04 0.269 0.635 0 0% 4 0 View 3D
BBS7 Zhang_et_al 0.173 8.65e-04 0.157 0.579 1 10% 10 0 View 3D
ARAF Zhang_et_al 0.150 1.81e-06 0.174 0.587 0 0% 17 0 View 3D
MAP3K1 Zhang_et_al 0.109 3.87e-02 0.096 0.548 — — 11 0 View 3D
MAP3K2 Zhang_et_al 0.153 1.43e-02 0.150 0.575 — — 6 0 View 3D
PGRMC1 Zhang_et_al 0.110 1.80e-02 0.133 0.567 — — 7 0 View 3D
MAPK3 Zhang_et_al 0.236 5.73e-08 0.278 0.639 1 12% 8 0 View 3D
MAPK8 Zhang_et_al 0.164 1.96e-06 0.190 0.595 2 14% 14 0 View 3D
MOS Zhang_et_al 0.178 4.26e-04 0.184 0.592 0 0% 8 0 View 3D
RAF1 Zhang_et_al 0.213 2.65e-11 0.234 0.617 0 0% 18 0 View 3D
MAP2K2 RCSB_PDB 0.138 9.19e-04 0.135 0.568 2 15% 13 0 View 3D
MAP2K2 RCSB_PDB 0.187 4.37e-06 0.200 0.600 2 15% 11 0 View 3D