MAP2K2 — Activity

🧬 View Structure

59 interactions

DMS Score Heatmap Scroll horizontally • click a column to see interactions • ■ purple strip = interface positions

PKc_MAP2K2 A V I L G F Y W C M P S T N Q D E H K R * 20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 0.50 1.00 2.17
Click a position to see interactions — ■ orange strip marks interface positions (darker = more interactions)

Significant Interactions

Interactor Predictor Log FC p-value (FDR) Cliff's Delta AUROC Unique Pos. % Unique # Interface Clashes Structure
KSR2 Predictomes -0.101 3.49e-05 -0.157 0.421 0 0% 15 0 View 3D
MAP4K5 Predictomes -0.008 9.63e-01 -0.003 0.499 — — 9 0 View 3D
MAP3K7 Predictomes -0.045 4.49e-02 -0.073 0.463 — — 18 0 View 3D
MAPK1 Predictomes -0.081 1.07e-04 -0.159 0.421 — — 13 0 View 3D
BRAF Predictomes -0.063 1.43e-02 -0.102 0.449 0 0% 13 0 View 3D
MAPK3 Predictomes -0.069 1.99e-04 -0.153 0.424 — — 13 0 View 3D
KSR2 Predictomes -0.088 2.91e-04 -0.142 0.429 0 0% 14 0 View 3D
WDR83 Predictomes -0.026 9.53e-01 -0.003 0.499 — — 11 0 View 3D
ARAF Predictomes -0.077 3.08e-04 -0.138 0.431 0 0% 15 0 View 3D
ARAF Predictomes -0.109 1.13e-05 -0.184 0.408 0 0% 12 0 View 3D
MAP2K1 Predictomes 0.100 3.68e-05 0.174 0.587 4 33% 12 0 View 3D
STK26 Predictomes -0.114 1.03e-05 -0.192 0.404 0 0% 11 0 View 3D
MAPK8 Predictomes -0.100 1.63e-03 -0.161 0.419 — — 8 0 View 3D
MAP2K1 Predictomes 0.027 3.21e-01 0.050 0.525 4 33% 9 0 View 3D
RAF1 Predictomes -0.079 1.19e-03 -0.124 0.438 0 0% 15 0 View 3D
STK26 Predictomes -0.132 1.92e-09 -0.220 0.390 0 0% 16 0 View 3D
MAP3K7 Predictomes 0.017 2.06e-01 0.051 0.525 — — 15 0 View 3D
MAP2K5 Predictomes 0.241 1.94e-09 0.481 0.741 3 100% 3 0 View 3D
MAP2K3 Predictomes -0.004 5.34e-01 -0.039 0.481 — — 6 0 View 3D
ARAF Predictomes -0.066 2.91e-03 -0.115 0.442 0 0% 15 0 View 3D
RAF1 Predictomes -0.089 1.40e-05 -0.161 0.419 0 0% 16 0 View 3D
MAP2K3 Predictomes 0.015 7.99e-01 0.015 0.507 — — 8 0 View 3D
MAP4K5 Predictomes 0.012 9.14e-01 -0.005 0.497 — — 12 0 View 3D
STK26 Predictomes -0.012 8.80e-01 -0.008 0.496 0 0% 8 0 View 3D
RAF1 Predictomes -0.140 1.09e-10 -0.250 0.375 0 0% 14 0 View 3D
WDR83 Predictomes -0.029 8.78e-01 -0.007 0.496 — — 11 0 View 3D
MAP2K5 Predictomes 0.173 6.12e-08 0.436 0.718 3 100% 3 0 View 3D
KSR1 Predictomes -0.001 5.30e-01 -0.025 0.488 0 0% 17 0 View 3D
WDR83 Predictomes 0.059 6.80e-02 0.086 0.543 — — 10 0 View 3D
MAP4K5 Predictomes -0.087 4.15e-04 -0.162 0.419 — — 10 0 View 3D
MOS Predictomes -0.007 4.98e-01 0.032 0.516 — — 11 0 View 3D
MAPK3 Predictomes -0.042 2.07e-02 -0.114 0.443 — — 9 0 View 3D
KSR1 Predictomes -0.076 8.84e-04 -0.121 0.440 0 0% 17 0 View 3D
MOS Predictomes 0.030 5.09e-03 0.124 0.562 — — 11 0 View 3D
MOS Predictomes -0.006 4.10e-01 0.039 0.519 — — 11 0 View 3D
BRAF Predictomes -0.069 2.67e-03 -0.123 0.438 0 0% 13 0 View 3D
MAPK1 Predictomes 0.013 8.25e-01 0.011 0.505 — — 11 0 View 3D
MAP2K1 Predictomes 0.094 1.24e-04 0.128 0.564 4 33% 21 0 View 3D
MAP3K7 Predictomes -0.058 3.35e-03 -0.103 0.449 — — 19 0 View 3D
BRAF Predictomes -0.148 3.68e-10 -0.251 0.375 0 0% 13 0 View 3D
MAPK3 Predictomes 0.014 8.04e-01 0.012 0.506 — — 11 0 View 3D
MAPK1 Predictomes -0.008 4.92e-01 -0.034 0.483 — — 10 0 View 3D
KSR2 Predictomes -0.112 1.03e-04 -0.147 0.426 0 0% 15 0 View 3D
MAP2K3 Predictomes 0.035 2.03e-01 0.072 0.536 — — 7 0 View 3D
KSR1 Predictomes -0.118 1.04e-06 -0.180 0.410 0 0% 16 0 View 3D
BRAF Zhang_et_al -0.046 1.38e-02 -0.114 0.443 — — 11 0 View 3D
MAPK1 Zhang_et_al 0.046 9.03e-02 0.107 0.554 — — 6 0 View 3D
RHOBTB2 Zhang_et_al 0.096 1.35e-04 0.273 0.637 — — 4 0 View 3D
BBS7 Zhang_et_al 0.066 4.51e-02 0.098 0.549 — — 10 0 View 3D
ARAF Zhang_et_al -0.027 1.04e-01 -0.064 0.468 — — 17 0 View 3D
MAP3K1 Zhang_et_al -0.022 2.10e-02 -0.105 0.447 — — 11 0 View 3D
MAP3K2 Zhang_et_al -0.077 1.90e-02 -0.143 0.429 — — 6 0 View 3D
PGRMC1 Zhang_et_al 0.031 2.96e-01 0.063 0.531 — — 7 0 View 3D
MAPK3 Zhang_et_al 0.043 4.46e-02 0.110 0.555 — — 8 0 View 3D
MAPK8 Zhang_et_al -0.051 5.51e-01 -0.029 0.486 — — 14 0 View 3D
MOS Zhang_et_al -0.004 6.99e-01 0.025 0.512 — — 8 0 View 3D
RAF1 Zhang_et_al -0.059 3.83e-03 -0.105 0.447 — — 18 0 View 3D
MAP2K2 RCSB_PDB 0.084 7.62e-08 0.216 0.608 — — 13 0 View 3D
MAP2K2 RCSB_PDB -0.080 1.22e-01 -0.070 0.465 — — 11 0 View 3D