PTPN11 — Abundance

🧬 View Structure

46 interactions

DMS Score Heatmap Scroll horizontally • click a column to see interactions • ■ purple strip = interface positions

SH2_N-SH2_SHP_like SH2_C-SH2_SHP_like PTPc-N11 A V I L G F Y W C M P S T N Q D E H K R * 20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 520 540 560 580 0.16 1.00 1.50
Click a position to see interactions — ■ orange strip marks interface positions (darker = more interactions)

Significant Interactions

Interactor Predictor Log FC p-value (FDR) Cliff's Delta AUROC Unique Pos. % Unique # Interface Clashes Structure
GAB1 Predictomes -0.014 3.91e-02 -0.064 0.468 — — 26 0 View 3D
GRB2 Predictomes 0.014 3.21e-01 0.039 0.520 — — 15 0 View 3D
THEMIS Predictomes -0.024 6.55e-02 -0.094 0.453 — — 9 0 View 3D
GAB2 Predictomes 0.005 7.57e-01 0.014 0.507 — — 13 0 View 3D
GRB2 Predictomes 0.013 3.40e-01 0.038 0.519 — — 15 0 View 3D
GAB3 Predictomes -0.019 2.15e-01 -0.065 0.467 — — 8 0 View 3D
SOS1 Predictomes 0.023 4.73e-02 0.084 0.542 — — 12 0 View 3D
SOS1 Predictomes 0.025 3.50e-02 0.089 0.545 — — 12 0 View 3D
FRS2 Predictomes -0.011 3.12e-01 -0.044 0.478 — — 12 0 View 3D
MPZL1 Predictomes 0.006 9.56e-01 0.002 0.501 — — 28 0 View 3D
THEMIS Predictomes -0.025 1.36e-02 -0.117 0.441 — — 10 0 View 3D
FRS2 Predictomes -0.006 5.66e-01 -0.026 0.487 — — 12 0 View 3D
GRB2 Predictomes 0.014 3.03e-01 0.040 0.520 — — 15 0 View 3D
FRS2 Predictomes 0.003 9.94e-01 -0.000 0.500 — — 13 0 View 3D
GAB3 Predictomes -0.009 1.71e-01 -0.044 0.478 — — 25 0 View 3D
GAB3 Predictomes -0.024 1.13e-01 -0.088 0.456 — — 7 0 View 3D
GAB2 Predictomes -0.008 5.53e-01 -0.026 0.487 — — 13 0 View 3D
GAB1 Predictomes -0.022 7.83e-02 -0.082 0.459 — — 10 0 View 3D
GAB2 Predictomes -0.004 3.65e-01 -0.029 0.486 — — 26 0 View 3D
SOS2 Zhang_et_al 0.033 5.67e-03 0.129 0.565 — — 10 0 View 3D
GAB3 Zhang_et_al -0.004 7.26e-01 -0.018 0.491 — — 13 0 View 3D
SOS1 Zhang_et_al 0.037 5.97e-04 0.152 0.576 — — 11 0 View 3D
HDGF Zhang_et_al -0.128 8.92e-04 -0.314 0.343 2 67% 3 0 View 3D
IL6ST Zhang_et_al -0.109 5.16e-04 -0.285 0.357 2 67% 3 0 View 3D
IRS1 RCSB_PDB -0.065 4.65e-05 -0.261 0.370 — — 5 0 View 3D
PTPN11 RCSB_PDB -0.106 4.10e-02 -0.170 0.415 — — 3 0 View 3D
PTPN11 RCSB_PDB 0.014 3.86e-01 0.065 0.532 — — 4 0 View 3D
FN1 RCSB_PDB 0.005 5.69e-01 0.051 0.525 — — 3 0 View 3D
PTPN11 RCSB_PDB -0.106 4.32e-02 -0.168 0.416 — — 3 0 View 3D
PTPN11 RCSB_PDB 0.015 3.27e-01 0.073 0.536 — — 4 0 View 3D
PTPN11 RCSB_PDB 0.012 4.13e-01 0.061 0.531 — — 4 0 View 3D
PTPN11 RCSB_PDB -0.104 4.43e-02 -0.167 0.416 — — 3 0 View 3D
PTPN11 RCSB_PDB -0.040 1.48e-03 -0.161 0.420 — — 8 0 View 3D
PTPN11 RCSB_PDB -0.042 9.11e-04 -0.167 0.416 — — 8 0 View 3D
CD28 RCSB_PDB -0.032 1.16e-01 -0.136 0.432 — — 3 0 View 3D
PDCD1 RCSB_PDB -0.012 8.62e-01 -0.011 0.494 — — 7 0 View 3D
GAB1 RCSB_PDB -0.018 5.43e-01 -0.033 0.484 — — 10 0 View 3D
GAB1 RCSB_PDB -0.024 2.07e-01 -0.069 0.466 — — 9 0 View 3D
PTPN11 RCSB_PDB -0.050 2.18e-04 -0.199 0.400 — — 7 0 View 3D
PTPN11 RCSB_PDB -0.052 1.43e-04 -0.205 0.398 — — 7 0 View 3D
GAB1 RCSB_PDB -0.013 9.04e-01 -0.007 0.497 — — 9 0 View 3D
cagA RCSB_PDB 0.007 4.22e-01 0.054 0.527 — — 5 0 View 3D
GAB1 RCSB_PDB -0.022 3.11e-01 -0.056 0.472 — — 9 0 View 3D
IRS1 RCSB_PDB -0.064 3.27e-03 -0.200 0.400 — — 5 0 View 3D
MPZL1 RCSB_PDB -0.013 2.29e-01 -0.043 0.478 — — 27 0 View 3D
TXNIP RCSB_PDB -0.002 8.50e-01 -0.011 0.494 — — 8 0 View 3D