PTPN11 — Activity

🧬 View Structure

46 interactions

DMS Score Heatmap Scroll horizontally • click a column to see interactions • ■ purple strip = interface positions

SH2_N-SH2_SHP_like SH2_C-SH2_SHP_like PTPc-N11 A V I L G F Y W C M P S T N Q D E H K R * 20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 520 540 560 580 0.47 1.00 1.74
Click a position to see interactions — ■ orange strip marks interface positions (darker = more interactions)

Significant Interactions

Interactor Predictor Log FC p-value (FDR) Cliff's Delta AUROC Unique Pos. % Unique # Interface Clashes Structure
GAB1 Predictomes -0.169 2.73e-58 -0.476 0.262 0 0% 26 0 View 3D
GRB2 Predictomes -0.100 6.84e-10 -0.226 0.387 — — 15 0 View 3D
THEMIS Predictomes -0.097 6.61e-14 -0.359 0.320 5 50% 9 0 View 3D
GAB2 Predictomes -0.199 6.05e-30 -0.447 0.277 2 15% 13 0 View 3D
GRB2 Predictomes -0.098 1.01e-09 -0.224 0.388 — — 15 0 View 3D
GAB3 Predictomes -0.219 7.21e-22 -0.473 0.263 0 0% 8 0 View 3D
SOS1 Predictomes -0.176 6.31e-22 -0.390 0.305 3 25% 12 0 View 3D
SOS1 Predictomes -0.172 1.40e-21 -0.386 0.307 3 25% 12 0 View 3D
FRS2 Predictomes -0.169 7.86e-20 -0.371 0.314 0 0% 12 0 View 3D
MPZL1 Predictomes 0.016 1.89e-18 -0.250 0.375 — — 28 0 View 3D
THEMIS Predictomes -0.107 1.09e-16 -0.376 0.312 5 50% 10 0 View 3D
FRS2 Predictomes -0.162 2.36e-18 -0.356 0.322 0 0% 12 0 View 3D
GRB2 Predictomes -0.093 8.79e-10 -0.225 0.388 — — 15 0 View 3D
FRS2 Predictomes -0.199 6.34e-23 -0.386 0.307 0 0% 13 0 View 3D
GAB3 Predictomes -0.151 7.69e-41 -0.398 0.301 0 0% 25 0 View 3D
GAB3 Predictomes -0.189 1.38e-20 -0.490 0.255 0 0% 7 0 View 3D
GAB2 Predictomes -0.211 1.41e-24 -0.401 0.300 2 15% 13 0 View 3D
GAB1 Predictomes -0.218 2.24e-26 -0.470 0.265 0 0% 10 0 View 3D
GAB2 Predictomes -0.153 1.62e-42 -0.401 0.300 2 15% 26 0 View 3D
SOS2 Zhang_et_al -0.069 4.54e-09 -0.263 0.369 — — 10 0 View 3D
GAB3 Zhang_et_al -0.156 1.26e-21 -0.378 0.311 1 8% 13 0 View 3D
SOS1 Zhang_et_al -0.103 5.38e-13 -0.308 0.346 2 18% 11 0 View 3D
HDGF Zhang_et_al 0.653 8.95e-01 -0.014 0.493 — — 3 0 View 3D
IL6ST Zhang_et_al 0.605 1.31e-02 0.208 0.604 — — 3 0 View 3D
IRS1 RCSB_PDB -0.035 6.41e-05 -0.256 0.372 1 20% 5 0 View 3D
PTPN11 RCSB_PDB -0.048 4.84e-02 -0.164 0.418 — — 3 0 View 3D
PTPN11 RCSB_PDB 0.027 3.93e-01 0.064 0.532 — — 4 0 View 3D
FN1 RCSB_PDB 0.102 9.52e-01 0.005 0.503 — — 3 0 View 3D
PTPN11 RCSB_PDB -0.054 4.43e-02 -0.167 0.417 — — 3 0 View 3D
PTPN11 RCSB_PDB 0.031 5.20e-01 0.049 0.524 — — 4 0 View 3D
PTPN11 RCSB_PDB 0.032 3.63e-01 0.068 0.534 — — 4 0 View 3D
PTPN11 RCSB_PDB -0.041 1.74e-01 -0.114 0.443 — — 3 0 View 3D
PTPN11 RCSB_PDB 0.001 7.11e-01 -0.021 0.490 — — 8 0 View 3D
PTPN11 RCSB_PDB 0.001 7.44e-01 -0.019 0.491 — — 8 0 View 3D
CD28 RCSB_PDB -0.272 2.22e-13 -0.595 0.203 0 0% 3 0 View 3D
PDCD1 RCSB_PDB -0.221 2.15e-15 -0.443 0.278 0 0% 7 0 View 3D
GAB1 RCSB_PDB -0.348 3.59e-31 -0.569 0.215 0 0% 10 0 View 3D
GAB1 RCSB_PDB -0.323 1.83e-27 -0.552 0.224 0 0% 9 0 View 3D
PTPN11 RCSB_PDB -0.037 5.78e-02 -0.106 0.447 — — 7 0 View 3D
PTPN11 RCSB_PDB -0.045 6.81e-02 -0.102 0.449 — — 7 0 View 3D
GAB1 RCSB_PDB -0.322 4.00e-25 -0.531 0.235 0 0% 9 0 View 3D
cagA RCSB_PDB -0.021 6.76e-05 -0.253 0.374 — — 5 0 View 3D
GAB1 RCSB_PDB -0.321 5.43e-26 -0.538 0.231 0 0% 9 0 View 3D
IRS1 RCSB_PDB 0.124 4.91e-06 -0.305 0.348 1 20% 5 0 View 3D
MPZL1 RCSB_PDB 0.065 2.60e-06 -0.160 0.420 — — 27 0 View 3D
TXNIP RCSB_PDB -0.155 1.28e-05 -0.221 0.389 1 12% 8 0 View 3D