RAF1 — Activity

🧬 View Structure

103 interactions

DMS Score Heatmap Scroll horizontally • click a column to see interactions • ■ purple strip = interface positions

RBD_RAF1 C1_A_C-Raf STKc_C-Raf A V I L G F Y W C M P S T N Q D E H K R * 20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 520 540 560 580 600 620 640 0.19 1.00 2.35
Click a position to see interactions — ■ orange strip marks interface positions (darker = more interactions)

Significant Interactions

Interactor Predictor Log FC p-value (FDR) Cliff's Delta AUROC Unique Pos. % Unique # Interface Clashes Structure
RAP1A Predictomes -0.783 3.48e-36 -0.612 0.194 0 0% 9 0 View 3D
CLEC16A Predictomes -0.902 1.51e-20 -0.640 0.180 0 0% 4 0 View 3D
MRAS Predictomes -0.454 3.19e-21 -0.443 0.279 0 0% 10 0 View 3D
ARAF Predictomes -0.609 3.68e-35 -0.486 0.257 0 0% 13 0 View 3D
KSR1 Predictomes -0.523 2.13e-33 -0.438 0.281 0 0% 16 0 View 3D
ARAF Predictomes -0.655 3.67e-40 -0.507 0.246 0 0% 14 0 View 3D
YWHAB Predictomes 0.599 8.62e-02 0.081 0.540 2 29% 10 0 View 3D
MAP2K1 Predictomes -0.142 1.99e-03 -0.113 0.443 1 9% 16 0 View 3D
LSM14A Predictomes 0.291 1.54e-03 0.184 0.592 — — 6 0 View 3D
RAP2A Predictomes -0.437 8.56e-15 -0.402 0.299 1 12% 8 0 View 3D
MAP2K3 Predictomes -0.233 1.94e-07 -0.245 0.377 0 0% 9 0 View 3D
RAP1B Predictomes -0.445 4.80e-24 -0.447 0.276 1 9% 11 0 View 3D
STK3 Predictomes -2.054 9.10e-32 -0.929 0.035 0 0% 3 0 View 3D
RAP1B Predictomes -0.692 1.85e-44 -0.585 0.208 1 9% 13 0 View 3D
GNB2 Predictomes -0.693 1.48e-26 -0.571 0.214 1 14% 7 0 View 3D
GNB2 Predictomes -0.820 3.34e-23 -0.583 0.208 1 14% 6 0 View 3D
KSR2 Predictomes -1.020 1.38e-63 -0.716 0.142 0 0% 11 0 View 3D
MAP2K5 Predictomes -0.111 8.65e-06 -0.157 0.422 1 6% 17 0 View 3D
TAOK1 Predictomes -0.302 2.33e-09 -0.316 0.342 0 0% 7 0 View 3D
MAP2K3 Predictomes -0.235 4.11e-07 -0.238 0.381 0 0% 9 0 View 3D
MAP2K1 Predictomes -0.181 1.93e-04 -0.161 0.420 1 9% 11 0 View 3D
MAP2K5 Predictomes -0.232 5.74e-07 -0.224 0.388 1 6% 10 0 View 3D
NRAS Predictomes -0.369 8.24e-23 -0.383 0.308 0 0% 14 0 View 3D
MAP2K2 Predictomes -0.036 6.73e-02 -0.068 0.466 — — 16 0 View 3D
BRAF Predictomes -0.684 2.31e-33 -0.513 0.244 0 0% 11 0 View 3D
CSNK1G1 Predictomes 0.347 1.28e-02 -0.109 0.445 0 0% 11 0 View 3D
STK3 Predictomes -0.202 7.61e-03 -0.189 0.405 0 0% 4 0 View 3D
SFN Predictomes 0.849 6.88e-12 0.324 0.662 2 22% 9 0 View 3D
YWHAB Predictomes 1.017 7.43e-18 0.456 0.728 2 29% 7 0 View 3D
KSR1 Predictomes -0.533 1.96e-33 -0.478 0.261 0 0% 13 0 View 3D
LSM14A Predictomes -0.132 6.65e-02 -0.152 0.424 — — 3 0 View 3D
NRAS Predictomes -0.363 1.09e-21 -0.372 0.314 0 0% 14 0 View 3D
MAP2K2 Predictomes -0.123 9.50e-03 -0.096 0.452 — — 16 0 View 3D
BRAF Predictomes -0.672 6.02e-33 -0.511 0.244 0 0% 11 0 View 3D
RAP1A Predictomes -0.277 2.39e-10 -0.264 0.368 0 0% 13 0 View 3D
KSR1 Predictomes -1.005 3.72e-62 -0.708 0.146 0 0% 11 0 View 3D
MAP2K6 Predictomes -0.296 2.19e-10 -0.315 0.343 0 0% 8 0 View 3D
NR3C1 Predictomes -0.365 9.84e-08 -0.336 0.332 0 0% 5 0 View 3D
MAP2K2 Predictomes -0.079 1.13e-03 -0.116 0.442 — — 17 0 View 3D
NRAS Predictomes -0.379 6.91e-24 -0.392 0.304 0 0% 14 0 View 3D
KRAS Predictomes -0.357 6.88e-21 -0.365 0.317 0 0% 14 0 View 3D
SFN Predictomes -0.215 1.46e-02 -0.173 0.414 2 22% 4 0 View 3D
MAP3K1 Predictomes -0.175 1.39e-04 -0.192 0.404 0 0% 8 0 View 3D
NR3C1 Predictomes 0.048 6.88e-01 -0.026 0.487 0 0% 6 0 View 3D
TAOK1 Predictomes -0.303 5.24e-12 -0.323 0.338 0 0% 9 0 View 3D
SFN Predictomes -0.134 1.71e-01 -0.089 0.455 2 22% 5 0 View 3D
LSM14A Predictomes 0.256 2.57e-01 0.083 0.542 — — 4 0 View 3D
RAP1B Predictomes -0.823 1.50e-62 -0.633 0.183 1 9% 15 0 View 3D
MAP3K1 Predictomes -0.337 2.31e-10 -0.365 0.317 0 0% 6 0 View 3D
MAP2K6 Predictomes -0.253 8.47e-08 -0.251 0.374 0 0% 9 0 View 3D
JAK2 Predictomes -0.156 7.22e-04 -0.136 0.432 1 8% 13 0 View 3D
RAP1A Predictomes -0.425 2.49e-20 -0.426 0.287 0 0% 10 0 View 3D
RRAS2 Predictomes -0.365 1.19e-20 -0.377 0.312 0 0% 13 0 View 3D
KRAS Predictomes -0.366 1.80e-22 -0.380 0.310 0 0% 14 0 View 3D
BRAF Predictomes -0.699 4.21e-34 -0.517 0.241 0 0% 11 0 View 3D
HRAS Predictomes -0.382 1.08e-23 -0.392 0.304 0 0% 14 0 View 3D
MAP2K5 Predictomes -0.203 4.91e-05 -0.204 0.398 1 6% 8 0 View 3D
HRAS Predictomes -0.360 5.25e-23 -0.375 0.312 0 0% 15 0 View 3D
MRAS Predictomes -0.380 3.54e-22 -0.375 0.313 0 0% 15 0 View 3D
NDUFA10 Predictomes 0.261 5.96e-02 0.122 0.561 21 100% 5 0 View 3D
KRAS Predictomes -0.400 1.14e-24 -0.400 0.300 0 0% 14 0 View 3D
ARAF Predictomes -0.672 3.52e-43 -0.525 0.237 0 0% 14 0 View 3D
KSR2 Predictomes -0.776 1.27e-59 -0.624 0.188 0 0% 14 0 View 3D
CSNK1G1 Predictomes 0.709 6.13e-05 0.201 0.601 0 0% 8 0 View 3D
MAP2K3 Predictomes -0.280 1.37e-09 -0.301 0.350 0 0% 8 0 View 3D
MAP2K6 Predictomes -0.255 9.25e-09 -0.269 0.365 0 0% 9 0 View 3D
HRAS Predictomes -0.396 2.75e-12 -0.322 0.339 0 0% 10 0 View 3D
TAOK1 Predictomes -0.144 3.46e-06 -0.210 0.395 0 0% 10 0 View 3D
MAP2K1 Predictomes -0.131 3.68e-03 -0.117 0.442 1 9% 13 0 View 3D
MRAS Predictomes -0.468 5.47e-20 -0.429 0.285 0 0% 10 0 View 3D
NDUFA10 Predictomes 0.206 3.82e-07 0.163 0.581 21 100% 21 0 View 3D
CLEC16A Predictomes -1.260 1.54e-87 -0.786 0.107 0 0% 13 0 View 3D
A0A1B0GUL7 Zhang_et_al -0.196 4.00e-04 -0.195 0.403 0 0% 7 0 View 3D
PPP1CB Zhang_et_al 0.960 9.52e-22 0.511 0.756 4 57% 7 0 View 3D
MAP2K1 Zhang_et_al -0.224 5.01e-06 -0.219 0.391 0 0% 9 0 View 3D
GNB2 Zhang_et_al -0.302 1.49e-08 -0.286 0.357 0 0% 9 0 View 3D
MAP2K2 Zhang_et_al -0.035 3.29e-01 -0.038 0.481 — — 18 0 View 3D
GNB1 Zhang_et_al -0.496 1.39e-27 -0.489 0.256 3 27% 11 0 View 3D
HSP90AB1 RCSB_PDB -0.271 3.19e-05 -0.242 0.379 4 67% 6 0 View 3D
RAP1A RCSB_PDB -0.597 3.81e-23 -0.644 0.178 0 0% 6 0 View 3D
HRAS RCSB_PDB -0.583 7.56e-24 -0.655 0.172 0 0% 6 0 View 3D
CDC37 RCSB_PDB -0.330 2.34e-17 -0.333 0.334 11 79% 14 0 View 3D
HRAS RCSB_PDB -0.441 1.43e-21 -0.419 0.291 0 0% 14 0 View 3D
HRAS RCSB_PDB -0.588 9.46e-24 -0.646 0.177 0 0% 6 0 View 3D
MAP2K1 RCSB_PDB 0.020 1.90e-01 -0.048 0.476 1 6% 19 0 View 3D
CDC37 RCSB_PDB -0.689 8.47e-32 -0.561 0.219 11 79% 9 0 View 3D
KRAS RCSB_PDB -0.467 3.06e-27 -0.467 0.266 0 0% 14 0 View 3D
CDC37 RCSB_PDB -0.669 1.79e-48 -0.577 0.212 11 79% 14 0 View 3D
HRAS RCSB_PDB -0.593 2.46e-20 -0.600 0.200 0 0% 6 0 View 3D
RAF1 RCSB_PDB -1.206 1.40e-73 -0.741 0.130 0 0% 12 0 View 3D
RAF1 RCSB_PDB -1.212 7.24e-74 -0.743 0.129 0 0% 12 0 View 3D
LOC113496266 RCSB_PDB -0.131 5.11e-02 -0.119 0.440 — — 6 0 View 3D
HSP90AB1 RCSB_PDB 0.206 1.23e-01 0.102 0.551 4 67% 5 0 View 3D
HRAS RCSB_PDB -0.529 9.51e-20 -0.586 0.207 0 0% 6 0 View 3D
KRAS RCSB_PDB -0.530 7.02e-23 -0.609 0.195 0 0% 7 0 View 3D
MAP2K1 RCSB_PDB -0.051 2.64e-04 -0.131 0.435 1 6% 18 0 View 3D
MAP2K1 RCSB_PDB -0.130 3.88e-08 -0.196 0.402 1 6% 18 0 View 3D
RAP1A RCSB_PDB -0.576 1.40e-29 -0.653 0.174 0 0% 8 0 View 3D
KRAS RCSB_PDB -0.602 2.21e-24 -0.663 0.169 0 0% 6 0 View 3D
KRAS RCSB_PDB -0.557 1.88e-22 -0.611 0.194 0 0% 7 0 View 3D
CDC37 RCSB_PDB -0.671 2.57e-36 -0.545 0.228 11 79% 11 0 View 3D
KRAS RCSB_PDB -0.461 2.80e-25 -0.457 0.272 0 0% 14 0 View 3D
RAP1A RCSB_PDB -0.555 3.75e-26 -0.637 0.181 0 0% 7 0 View 3D