SOS1 — Abundance

🧬 View Structure

47 interactions

DMS Score Heatmap Scroll horizontally • click a column to see interactions • ■ purple strip = interface positions

PH_SOS RasGEFN RasGEF A V I L G F Y W C M P S T N Q D E H K R * 540 560 580 600 620 640 660 680 700 720 740 760 780 800 820 840 860 880 900 920 0.31 1.00 1.50
Click a position to see interactions — ■ orange strip marks interface positions (darker = more interactions)

Significant Interactions

Interactor Predictor Log FC p-value (FDR) Cliff's Delta AUROC Unique Pos. % Unique # Interface Clashes Structure
RAC1 Predictomes 0.235 2.04e-40 0.577 0.789 0 0% 11 0 View 3D
KRAS Predictomes 0.174 1.95e-31 0.453 0.727 0 0% 14 0 View 3D
RIT2 Predictomes 0.091 1.83e-09 0.255 0.628 0 0% 12 0 View 3D
PTPN6 Predictomes -0.038 2.38e-01 -0.102 0.449 — — 3 0 View 3D
NRAS Predictomes 0.172 5.56e-31 0.450 0.725 0 0% 14 0 View 3D
NRAS Predictomes 0.178 1.92e-36 0.476 0.738 0 0% 15 0 View 3D
RIT2 Predictomes 0.148 1.66e-24 0.410 0.705 0 0% 13 0 View 3D
RIT2 Predictomes 0.075 3.41e-07 0.203 0.602 0 0% 14 0 View 3D
KRAS Predictomes 0.121 1.90e-12 0.341 0.671 0 0% 9 0 View 3D
PTPN11 Predictomes -0.037 2.32e-01 -0.103 0.449 — — 3 0 View 3D
PTPN11 Predictomes -0.044 6.54e-02 -0.134 0.433 — — 4 0 View 3D
HRAS Predictomes 0.172 5.21e-31 0.450 0.725 0 0% 14 0 View 3D
RAC1 Predictomes 0.191 7.13e-09 0.460 0.730 0 0% 3 0 View 3D
NRAS Predictomes 0.117 2.72e-12 0.309 0.654 0 0% 11 0 View 3D
HRAS Predictomes 0.185 2.71e-37 0.481 0.740 0 0% 15 0 View 3D
RIT1 Predictomes 0.158 6.69e-26 0.421 0.711 0 0% 13 0 View 3D
RIT1 Predictomes 0.157 1.64e-25 0.419 0.709 0 0% 13 0 View 3D
HRAS Predictomes 0.186 1.90e-37 0.484 0.742 0 0% 15 0 View 3D
RIT1 Predictomes 0.085 3.06e-07 0.237 0.618 0 0% 10 0 View 3D
RAC1 Predictomes 0.176 2.36e-15 0.421 0.710 0 0% 7 0 View 3D
PTPN6 Predictomes -0.043 6.74e-02 -0.134 0.433 — — 4 0 View 3D
KRAS Predictomes 0.184 8.17e-37 0.478 0.739 0 0% 15 0 View 3D
SOS2 Zhang_et_al 0.034 4.73e-02 0.133 0.566 — — 5 0 View 3D
RASL11A Zhang_et_al 0.196 1.14e-28 0.524 0.762 0 0% 9 0 View 3D
FOXO1 Zhang_et_al 0.156 1.40e-16 0.438 0.719 0 0% 7 0 View 3D
RERG Zhang_et_al 0.203 7.21e-24 0.501 0.751 0 0% 8 0 View 3D
C3orf18 Zhang_et_al 0.160 2.37e-15 0.425 0.712 0 0% 7 0 View 3D
ITSN1 Zhang_et_al 0.167 4.67e-21 0.450 0.725 2 22% 9 0 View 3D
ITSN1 Zhang_et_al 0.019 8.09e-01 0.018 0.509 2 22% 6 0 View 3D
BLNK Zhang_et_al 0.093 3.39e-07 0.247 0.624 — — 9 0 View 3D
RAP1A Zhang_et_al 0.170 6.15e-30 0.443 0.722 0 0% 14 0 View 3D
RERGL Zhang_et_al 0.272 8.52e-29 0.693 0.847 0 0% 5 0 View 3D
RASL11B Zhang_et_al 0.169 1.60e-20 0.439 0.719 0 0% 9 0 View 3D
ARHGAP39 Zhang_et_al 0.304 8.32e-20 0.729 0.864 0 0% 3 0 View 3D
EGFR Zhang_et_al 0.045 1.80e-01 0.078 0.539 — — 8 0 View 3D
NCK2 Zhang_et_al 0.128 2.32e-12 0.375 0.688 0 0% 7 0 View 3D
ATRX Zhang_et_al 0.176 3.38e-16 0.411 0.705 3 38% 8 0 View 3D
KRAS RCSB_PDB 0.161 7.80e-29 0.433 0.716 0 0% 14 0 View 3D
HRAS RCSB_PDB 0.082 9.93e-09 0.210 0.605 0 0% 17 0 View 3D
KRAS RCSB_PDB 0.163 3.59e-29 0.436 0.718 0 0% 14 0 View 3D
HRAS RCSB_PDB 0.085 5.17e-09 0.220 0.610 0 0% 16 0 View 3D
KRAS RCSB_PDB 0.154 1.43e-27 0.425 0.712 0 0% 14 0 View 3D
KRAS RCSB_PDB 0.165 6.80e-29 0.435 0.717 0 0% 14 0 View 3D
HRAS RCSB_PDB 0.089 1.65e-09 0.226 0.613 0 0% 16 0 View 3D
KRAS RCSB_PDB 0.165 3.27e-29 0.437 0.718 0 0% 14 0 View 3D
HRAS RCSB_PDB 0.168 1.36e-30 0.444 0.722 0 0% 14 0 View 3D
HRAS RCSB_PDB 0.164 6.56e-30 0.439 0.720 0 0% 14 0 View 3D