SOS1 — Activity

🧬 View Structure

47 interactions

DMS Score Heatmap Scroll horizontally • click a column to see interactions • ■ purple strip = interface positions

PH_SOS RasGEFN RasGEF A V I L G F Y W C M P S T N Q D E H K R * 540 560 580 600 620 640 660 680 700 720 740 760 780 800 820 840 860 880 900 920 0.15 1.00 2.22
Click a position to see interactions — ■ orange strip marks interface positions (darker = more interactions)

Significant Interactions

Interactor Predictor Log FC p-value (FDR) Cliff's Delta AUROC Unique Pos. % Unique # Interface Clashes Structure
RAC1 Predictomes -1.384 7.55e-79 -0.808 0.096 0 0% 11 0 View 3D
KRAS Predictomes -1.295 3.13e-92 -0.784 0.108 0 0% 14 0 View 3D
RIT2 Predictomes -0.232 3.41e-11 -0.277 0.362 0 0% 12 0 View 3D
PTPN6 Predictomes 0.563 2.47e-04 0.295 0.648 0 0% 3 0 View 3D
NRAS Predictomes -1.292 1.58e-91 -0.782 0.109 0 0% 14 0 View 3D
NRAS Predictomes -1.271 6.69e-99 -0.791 0.105 0 0% 15 0 View 3D
RIT2 Predictomes -1.225 4.22e-83 -0.768 0.116 0 0% 13 0 View 3D
RIT2 Predictomes -0.004 1.58e-04 -0.150 0.425 0 0% 14 0 View 3D
KRAS Predictomes -0.387 3.58e-18 -0.413 0.294 0 0% 9 0 View 3D
PTPN11 Predictomes 0.571 1.75e-04 0.302 0.651 0 0% 3 0 View 3D
PTPN11 Predictomes 0.610 7.58e-08 0.373 0.686 0 0% 4 0 View 3D
HRAS Predictomes -1.295 8.43e-92 -0.783 0.109 0 0% 14 0 View 3D
RAC1 Predictomes -1.015 2.61e-18 -0.689 0.155 0 0% 3 0 View 3D
NRAS Predictomes -0.198 1.83e-14 -0.332 0.334 0 0% 11 0 View 3D
HRAS Predictomes -1.261 1.02e-97 -0.784 0.108 0 0% 15 0 View 3D
RIT1 Predictomes -1.221 3.60e-83 -0.767 0.117 0 0% 13 0 View 3D
RIT1 Predictomes -1.220 5.64e-82 -0.763 0.119 0 0% 13 0 View 3D
HRAS Predictomes -1.277 1.76e-99 -0.795 0.102 0 0% 15 0 View 3D
RIT1 Predictomes -0.184 3.94e-07 -0.231 0.385 0 0% 10 0 View 3D
RAC1 Predictomes -1.066 4.02e-40 -0.699 0.151 0 0% 7 0 View 3D
PTPN6 Predictomes 0.614 5.69e-08 0.376 0.688 0 0% 4 0 View 3D
KRAS Predictomes -1.256 1.05e-96 -0.781 0.109 0 0% 15 0 View 3D
SOS2 Zhang_et_al -0.070 8.95e-01 -0.010 0.495 — — 5 0 View 3D
RASL11A Zhang_et_al -1.381 2.32e-69 -0.826 0.087 0 0% 9 0 View 3D
FOXO1 Zhang_et_al -1.221 2.20e-49 -0.776 0.112 0 0% 7 0 View 3D
RERG Zhang_et_al -1.096 4.28e-46 -0.704 0.148 0 0% 8 0 View 3D
C3orf18 Zhang_et_al -1.190 3.63e-45 -0.743 0.128 0 0% 7 0 View 3D
ITSN1 Zhang_et_al -1.336 5.60e-63 -0.787 0.107 1 11% 9 0 View 3D
ITSN1 Zhang_et_al 0.019 1.20e-01 0.100 0.550 1 11% 6 0 View 3D
BLNK Zhang_et_al -0.667 2.19e-23 -0.471 0.264 2 22% 9 0 View 3D
RAP1A Zhang_et_al -1.303 2.16e-91 -0.781 0.110 0 0% 14 0 View 3D
RERGL Zhang_et_al -1.932 7.66e-51 -0.929 0.036 0 0% 5 0 View 3D
RASL11B Zhang_et_al -1.158 3.95e-54 -0.727 0.136 0 0% 9 0 View 3D
ARHGAP39 Zhang_et_al -1.912 1.08e-30 -0.911 0.044 0 0% 3 0 View 3D
EGFR Zhang_et_al -0.364 4.89e-07 -0.262 0.369 5 62% 8 0 View 3D
NCK2 Zhang_et_al -1.272 1.86e-48 -0.771 0.115 0 0% 7 0 View 3D
ATRX Zhang_et_al -1.005 4.03e-34 -0.603 0.198 2 25% 8 0 View 3D
KRAS RCSB_PDB -1.194 3.26e-85 -0.751 0.124 0 0% 14 0 View 3D
HRAS RCSB_PDB 0.026 5.21e-04 -0.127 0.437 0 0% 17 0 View 3D
KRAS RCSB_PDB -1.198 8.36e-86 -0.755 0.122 0 0% 14 0 View 3D
HRAS RCSB_PDB 0.018 7.77e-05 -0.148 0.426 0 0% 16 0 View 3D
KRAS RCSB_PDB -1.209 6.22e-86 -0.759 0.121 0 0% 14 0 View 3D
KRAS RCSB_PDB -1.201 4.97e-85 -0.753 0.124 0 0% 14 0 View 3D
HRAS RCSB_PDB 0.013 4.53e-05 -0.152 0.424 0 0% 16 0 View 3D
KRAS RCSB_PDB -1.201 8.86e-86 -0.756 0.122 0 0% 14 0 View 3D
HRAS RCSB_PDB -1.217 1.58e-88 -0.764 0.118 0 0% 14 0 View 3D
HRAS RCSB_PDB -1.210 2.00e-88 -0.763 0.118 0 0% 14 0 View 3D