BRAF — Activity

🧬 View Structure

82 interactions

DMS Score Heatmap Scroll horizontally • click a column to see interactions • ■ purple strip = interface positions

RBD_BRAF C1_B-Raf STKc_Raf A V I L G F Y W C M P S T N Q D E H K R * 20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 520 540 560 580 600 620 640 660 680 700 720 740 760 0.36 1.00 9.43
Click a position to see interactions — ■ orange strip marks interface positions (darker = more interactions)

Significant Interactions

Interactor Predictor Log FC p-value (FDR) Cliff's Delta AUROC Unique Pos. % Unique # Interface Clashes Structure
MAP2K7 Predictomes 0.049 6.49e-18 0.530 0.765 — — 5 0 View 3D
ARAF Predictomes -0.965 4.81e-45 -0.640 0.180 0 0% 10 0 View 3D
MAP2K2 Predictomes -0.174 4.05e-21 0.385 0.693 1 8% 12 0 View 3D
MAP2K3 Predictomes -0.016 1.24e-26 0.524 0.762 0 0% 8 0 View 3D
MRAS Predictomes -0.461 6.38e-03 -0.146 0.427 5 45% 8 0 View 3D
HRAS Predictomes -0.267 5.35e-02 -0.099 0.450 — — 9 0 View 3D
KRAS Predictomes 0.479 5.72e-01 0.026 0.513 — — 12 0 View 3D
NRAS Predictomes 0.604 1.09e-01 0.069 0.535 — — 13 0 View 3D
MAP2K6 Predictomes -0.094 1.01e-24 0.504 0.752 0 0% 8 0 View 3D
STK11 Predictomes -0.205 3.63e-19 0.364 0.682 1 8% 12 0 View 3D
RAP1B Predictomes -0.296 1.95e-02 -0.130 0.435 0 0% 7 0 View 3D
RAP1A Predictomes -0.635 4.28e-08 -0.278 0.361 0 0% 8 0 View 3D
KSR2 Predictomes -0.865 2.37e-46 -0.488 0.256 1 5% 20 0 View 3D
KSR1 Predictomes -0.735 1.41e-38 -0.483 0.258 0 0% 16 0 View 3D
HRAS Predictomes 0.731 5.82e-02 0.087 0.544 — — 11 0 View 3D
MAP2K6 Predictomes -0.127 4.20e-20 0.426 0.713 0 0% 9 0 View 3D
NRAS Predictomes 0.643 2.66e-01 0.053 0.526 — — 11 0 View 3D
STK11 Predictomes -0.202 3.91e-21 0.398 0.699 1 8% 11 0 View 3D
KRAS Predictomes 0.548 2.56e-01 0.052 0.526 — — 12 0 View 3D
RAF1 Predictomes -0.856 9.78e-43 -0.623 0.189 0 0% 10 0 View 3D
MRAS Predictomes -0.547 9.98e-05 -0.180 0.410 5 45% 11 0 View 3D
KSR2 Predictomes -0.779 8.53e-50 -0.502 0.249 1 5% 20 0 View 3D
MAP2K1 Predictomes -0.136 3.44e-14 0.336 0.668 0 0% 10 0 View 3D
MAP2K6 Predictomes -0.026 2.20e-26 0.521 0.761 0 0% 8 0 View 3D
MAP2K3 Predictomes -0.104 1.39e-25 0.442 0.721 0 0% 11 0 View 3D
MAP2K7 Predictomes -0.069 4.74e-11 0.406 0.703 — — 5 0 View 3D
HRAS Predictomes 0.669 6.82e-02 0.078 0.539 — — 13 0 View 3D
NRAS Predictomes 0.576 2.40e-01 0.051 0.526 — — 13 0 View 3D
KSR1 Predictomes -0.706 2.28e-39 -0.439 0.281 0 0% 21 0 View 3D
ITCH Predictomes 1.186 4.58e-41 0.630 0.815 5 56% 9 0 View 3D
ARAF Predictomes -1.012 1.18e-52 -0.663 0.168 0 0% 11 0 View 3D
RAF1 Predictomes -0.837 1.12e-43 -0.632 0.184 0 0% 10 0 View 3D
KSR1 Predictomes -0.636 7.41e-35 -0.411 0.294 0 0% 21 0 View 3D
MAP2K7 Predictomes -0.065 2.77e-15 0.486 0.743 — — 5 0 View 3D
ARAF Predictomes -0.842 1.05e-52 -0.636 0.182 0 0% 12 0 View 3D
MRAS Predictomes 0.254 5.43e-01 -0.031 0.485 5 45% 10 0 View 3D
STK11 Predictomes -0.183 1.14e-22 0.414 0.707 1 8% 11 0 View 3D
MAP2K1 Predictomes -0.155 6.47e-19 0.393 0.697 0 0% 10 0 View 3D
RAF1 Predictomes -0.832 3.36e-43 -0.626 0.187 0 0% 10 0 View 3D
MAP2K2 Predictomes -0.175 1.11e-15 0.355 0.678 1 8% 10 0 View 3D
MAP2K3 Predictomes -0.074 5.67e-23 0.458 0.729 0 0% 9 0 View 3D
ITCH Predictomes 1.089 3.13e-37 0.601 0.800 5 56% 9 0 View 3D
MAP2K2 Predictomes -0.005 1.22e-22 0.374 0.687 1 8% 14 0 View 3D
RAP1B Predictomes -0.425 3.09e-03 -0.158 0.421 0 0% 8 0 View 3D
MAP2K1 Predictomes 0.018 5.67e-23 0.388 0.694 0 0% 13 0 View 3D
RAP1B Predictomes -0.617 9.53e-05 -0.213 0.394 0 0% 7 0 View 3D
RAP1A Predictomes -0.483 1.45e-03 -0.174 0.413 0 0% 7 0 View 3D
RAP1A Predictomes -0.448 2.27e-03 -0.163 0.418 0 0% 8 0 View 3D
A0A1B0GUL7 Zhang_et_al -0.147 9.08e-16 0.399 0.699 0 0% 8 0 View 3D
MAP2K2 Zhang_et_al 0.415 9.38e-26 0.491 0.746 0 0% 9 0 View 3D
MAP2K1 Zhang_et_al -0.065 4.55e-25 0.460 0.730 — — 10 0 View 3D
KSR2 Zhang_et_al -0.991 1.15e-68 -0.724 0.138 0 0% 12 0 View 3D
KSR2 Zhang_et_al -0.604 5.97e-02 -0.098 0.451 0 0% 10 0 View 3D
KSR1 Zhang_et_al -0.671 1.94e-36 -0.423 0.289 1 5% 21 0 View 3D
STK11 Zhang_et_al -0.244 9.08e-16 0.358 0.679 1 10% 10 0 View 3D
CDC37 RCSB_PDB -0.493 1.02e-38 -0.563 0.219 9 82% 11 0 View 3D
YWHAZ RCSB_PDB 0.002 4.54e-04 0.192 0.596 2 20% 7 0 View 3D
MAP2K1 RCSB_PDB 0.248 4.94e-29 0.424 0.712 3 20% 15 0 View 3D
V9P4T4 RCSB_PDB 1.358 1.41e-20 0.425 0.713 1 10% 10 0 View 3D
V9P4T4 RCSB_PDB 1.181 4.57e-15 0.349 0.674 1 10% 11 0 View 3D
CDC37 RCSB_PDB -0.458 9.26e-34 -0.599 0.200 9 82% 8 0 View 3D
KRAS RCSB_PDB -0.550 3.03e-05 -0.244 0.378 0 0% 6 0 View 3D
MAP2K1 RCSB_PDB 0.080 1.00e-26 0.388 0.694 3 20% 17 0 View 3D
BRAF RCSB_PDB -1.234 4.72e-61 -0.721 0.139 1 9% 11 0 View 3D
BRAF RCSB_PDB -0.734 5.68e-45 -0.620 0.190 1 9% 11 0 View 3D
BRAF RCSB_PDB -0.696 1.49e-38 -0.572 0.214 1 9% 11 0 View 3D
BRAF RCSB_PDB -1.099 2.69e-62 -0.701 0.150 1 9% 12 0 View 3D
BRAF RCSB_PDB 0.719 9.99e-03 0.101 0.551 1 9% 15 0 View 3D
BRAF RCSB_PDB -0.227 1.87e-03 0.129 0.565 1 9% 13 0 View 3D
BRAF RCSB_PDB -0.601 3.68e-40 -0.544 0.228 1 9% 13 0 View 3D
BRAF RCSB_PDB -0.790 6.14e-50 -0.609 0.195 1 9% 13 0 View 3D
V9P4T4 RCSB_PDB 1.058 1.66e-04 0.156 0.578 1 10% 13 0 View 3D
HSP90AB1 RCSB_PDB 0.245 8.96e-01 -0.010 0.495 — — 4 0 View 3D
MAP2K1 RCSB_PDB -0.002 4.33e-31 0.420 0.710 3 20% 17 0 View 3D
YWHAZ RCSB_PDB 1.346 3.00e-29 0.513 0.757 2 20% 10 0 View 3D
YWHAZ RCSB_PDB -0.516 3.10e-01 0.068 0.534 2 20% 5 0 View 3D
YWHAZ RCSB_PDB -0.242 8.05e-01 -0.013 0.494 2 20% 10 0 View 3D
CDC37 RCSB_PDB -0.497 4.79e-40 -0.574 0.213 9 82% 11 0 View 3D
MAP2K1 RCSB_PDB 0.107 6.27e-29 0.405 0.702 3 20% 17 0 View 3D
HSP90AB1 RCSB_PDB 0.230 7.86e-01 -0.022 0.489 — — 4 0 View 3D
YWHAZ RCSB_PDB -0.138 2.96e-01 0.070 0.535 2 20% 5 0 View 3D
KRAS RCSB_PDB -0.552 7.60e-04 -0.200 0.400 0 0% 6 0 View 3D