ERBB2 — Activity

🧬 View Structure

36 interactions

DMS Score Heatmap Scroll horizontally • click a column to see interactions • ■ purple strip = interface positions

PTKc_HER2 A V I L G F Y W C M P S T N Q D E H K R * 700 720 740 760 780 800 820 840 860 880 900 920 940 960 980 1000 1020 1040 1060 1080 1100 1120 1140 1160 1180 1200 1220 1240 0.36 1.00 1.71
Click a position to see interactions — ■ orange strip marks interface positions (darker = more interactions)

Significant Interactions

Interactor Predictor Log FC p-value (FDR) Cliff's Delta AUROC Unique Pos. % Unique # Interface Clashes Structure
ERRFI1 Predictomes -0.216 3.24e-11 -0.243 0.378 13 57% 23 0 View 3D
GRM1 Predictomes -0.060 3.28e-02 -0.129 0.435 — — 7 0 View 3D
ERRFI1 Predictomes -0.237 1.69e-13 -0.264 0.368 13 57% 24 0 View 3D
PC Predictomes -0.259 2.03e-06 -0.235 0.382 3 27% 11 0 View 3D
ERBB4 Predictomes 0.088 1.08e-01 -0.065 0.468 — — 19 0 View 3D
ERBB3 Predictomes 0.041 2.94e-02 -0.087 0.457 — — 19 0 View 3D
EGFR Predictomes 0.027 8.81e-03 -0.098 0.451 — — 22 0 View 3D
SOCS3 Predictomes 0.033 6.01e-03 0.184 0.592 0 0% 5 0 View 3D
SOCS3 Predictomes -0.068 3.60e-01 0.056 0.528 0 0% 7 0 View 3D
SOCS3 Predictomes -0.576 3.13e-16 -0.549 0.225 0 0% 5 0 View 3D
ERBB3 Predictomes 0.082 1.62e-01 -0.061 0.469 — — 16 0 View 3D
PC Predictomes -0.302 8.71e-10 -0.280 0.360 3 27% 13 0 View 3D
ERBB4 Predictomes -0.017 8.65e-05 -0.153 0.423 — — 19 0 View 3D
ERBB3 Predictomes -0.010 1.06e-03 -0.124 0.438 — — 21 0 View 3D
CPNE3 Zhang_et_al 0.250 1.38e-21 0.389 0.695 7 50% 14 0 View 3D
VAV3 Zhang_et_al -0.515 9.66e-14 -0.461 0.270 1 17% 6 0 View 3D
TIMM50 Zhang_et_al 0.181 4.88e-06 0.354 0.677 0 0% 4 0 View 3D
ERBB3 Zhang_et_al 0.046 4.78e-01 -0.029 0.486 — — 25 0 View 3D
MATK Zhang_et_al 0.167 2.38e-07 0.268 0.634 6 67% 9 0 View 3D
CD44 Zhang_et_al -0.309 3.26e-07 -0.357 0.321 1 20% 5 0 View 3D
ANK1 Zhang_et_al -0.180 3.85e-02 -0.167 0.417 — — 4 0 View 3D
ERBB4 Zhang_et_al 0.042 2.26e-01 -0.049 0.476 — — 22 0 View 3D
LRPPRC Zhang_et_al 0.252 2.18e-21 0.535 0.767 5 71% 7 0 View 3D
NOTCH2 Zhang_et_al -0.135 2.42e-01 -0.091 0.455 — — 5 0 View 3D
NOTCH2 Zhang_et_al -0.048 7.34e-01 0.027 0.514 — — 6 0 View 3D
IQGAP1 Zhang_et_al -0.216 2.01e-03 -0.171 0.414 — — 9 0 View 3D
VAV1 Zhang_et_al -0.100 3.50e-01 -0.078 0.461 1 14% 4 0 View 3D
VAV1 Zhang_et_al -0.726 1.20e-34 -0.686 0.157 1 14% 7 0 View 3D
MEPCE Zhang_et_al 0.226 3.23e-26 0.470 0.735 10 91% 11 0 View 3D
JMJD4 Zhang_et_al 0.247 2.63e-24 0.518 0.759 8 100% 8 0 View 3D
VAV2 Zhang_et_al -0.202 2.68e-03 -0.173 0.413 — — 8 0 View 3D
EGLN3 Zhang_et_al 0.342 2.76e-01 0.108 0.554 — — 3 0 View 3D
CBLC Zhang_et_al 0.259 3.17e-25 0.527 0.763 1 12% 8 0 View 3D
NXT1 Zhang_et_al 0.251 8.31e-18 0.504 0.752 3 50% 6 0 View 3D
SH2D3C Zhang_et_al -0.672 1.07e-32 -0.615 0.192 0 0% 9 0 View 3D
LRRC15 Zhang_et_al 0.252 4.34e-11 0.536 0.768 0 0% 3 0 View 3D