ARAF — Abundance_hsp90i

🧬 View Structure

66 interactions

DMS Score Heatmap Scroll horizontally • click a column to see interactions • ■ purple strip = interface positions

RBD_ARAF C1_A_C-Raf STKc_A-Raf A V I L G F Y W C M P S T N Q D E H K R * 20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 520 540 560 580 600 0.45 1.00 1.50
Click a position to see interactions — ■ orange strip marks interface positions (darker = more interactions)

Significant Interactions

Interactor Predictor Log FC p-value (FDR) Cliff's Delta AUROC Unique Pos. % Unique # Interface Clashes Structure
KSR1 Predictomes 0.016 2.14e-01 0.054 0.527 — — 13 0 View 3D
MAP2K1 Predictomes -0.168 3.08e-25 -0.424 0.288 0 0% 13 0 View 3D
YWHAH Predictomes -0.031 9.58e-03 -0.109 0.446 — — 13 0 View 3D
BRAF Predictomes -0.050 7.53e-03 -0.121 0.440 — — 11 0 View 3D
YWHAH Predictomes -0.012 2.19e-01 -0.056 0.472 — — 12 0 View 3D
RRAS2 Predictomes 0.149 1.21e-30 0.455 0.728 0 0% 14 0 View 3D
YWHAG Predictomes -0.020 6.15e-02 -0.080 0.460 — — 13 0 View 3D
YWHAH Predictomes -0.019 8.70e-02 -0.076 0.462 — — 12 0 View 3D
RAF1 Predictomes -0.021 2.14e-01 -0.052 0.474 — — 14 0 View 3D
RAF1 Predictomes -0.024 2.10e-01 -0.053 0.473 — — 14 0 View 3D
SFN Predictomes 0.032 3.86e-01 0.050 0.525 — — 7 0 View 3D
MAP2K3 Predictomes -0.185 6.26e-21 -0.469 0.265 0 0% 8 0 View 3D
MAP2K3 Predictomes -0.163 7.80e-18 -0.408 0.296 0 0% 9 0 View 3D
MAP2K2 Predictomes -0.170 1.96e-27 -0.427 0.287 0 0% 14 0 View 3D
MAP2K2 Predictomes -0.167 8.78e-25 -0.420 0.290 0 0% 13 0 View 3D
YWHAB Predictomes -0.014 1.63e-01 -0.060 0.470 — — 13 0 View 3D
YWHAB Predictomes 0.014 8.96e-01 0.006 0.503 — — 14 0 View 3D
KSR1 Predictomes -0.015 5.26e-01 -0.028 0.486 — — 13 0 View 3D
MAP2K5 Predictomes -0.181 5.27e-29 -0.489 0.256 1 9% 11 0 View 3D
YWHAZ Predictomes -0.008 3.48e-01 -0.043 0.479 — — 12 0 View 3D
RRAS Predictomes 0.209 1.67e-32 0.601 0.801 0 0% 8 0 View 3D
NRAS Predictomes 0.147 4.42e-30 0.450 0.725 0 0% 14 0 View 3D
YWHAZ Predictomes -0.022 5.00e-02 -0.083 0.458 — — 13 0 View 3D
MAP2K5 Predictomes -0.208 3.46e-30 -0.540 0.230 1 9% 9 0 View 3D
NRAS Predictomes 0.151 1.39e-30 0.453 0.727 0 0% 14 0 View 3D
KRAS Predictomes 0.140 8.58e-29 0.436 0.718 0 0% 14 0 View 3D
MAP2K1 Predictomes -0.170 3.66e-27 -0.425 0.288 0 0% 14 0 View 3D
MAP2K2 Predictomes -0.158 3.90e-25 -0.397 0.301 0 0% 15 0 View 3D
MAP2K5 Predictomes -0.216 1.52e-46 -0.551 0.225 1 9% 15 0 View 3D
YWHAQ Predictomes -0.013 1.81e-01 -0.060 0.470 — — 12 0 View 3D
KRAS Predictomes 0.146 1.05e-29 0.446 0.723 0 0% 14 0 View 3D
STK11 Predictomes -0.139 2.58e-17 -0.353 0.323 1 8% 12 0 View 3D
BRAF Predictomes -0.058 5.45e-04 -0.154 0.423 — — 11 0 View 3D
STK11 Predictomes -0.139 4.86e-17 -0.353 0.324 1 8% 12 0 View 3D
HRAS Predictomes 0.142 2.95e-29 0.441 0.720 0 0% 14 0 View 3D
YWHAQ Predictomes -0.029 1.33e-02 -0.105 0.448 — — 13 0 View 3D
HRAS Predictomes 0.142 1.34e-25 0.440 0.720 0 0% 12 0 View 3D
KSR2 Predictomes 0.014 1.36e-01 0.062 0.531 — — 14 0 View 3D
YWHAZ Predictomes -0.008 2.67e-01 -0.048 0.476 — — 13 0 View 3D
RRAS2 Predictomes 0.149 6.56e-33 0.458 0.729 0 0% 15 0 View 3D
BRAF Predictomes -0.034 7.04e-02 -0.078 0.461 — — 13 0 View 3D
YWHAE Predictomes -0.000 6.59e-01 -0.021 0.490 — — 12 0 View 3D
YWHAG Predictomes 0.044 7.26e-02 0.095 0.547 — — 8 0 View 3D
YWHAE Predictomes -0.017 1.19e-01 -0.067 0.466 — — 13 0 View 3D
YWHAG Predictomes 0.016 8.17e-01 0.013 0.507 — — 8 0 View 3D
YWHAQ Predictomes -0.000 3.68e-01 -0.041 0.479 — — 12 0 View 3D
YWHAE Predictomes -0.011 2.47e-01 -0.052 0.474 — — 12 0 View 3D
MAP2K3 Predictomes -0.187 3.17e-21 -0.472 0.264 0 0% 8 0 View 3D
STK11 Predictomes -0.121 4.72e-13 -0.306 0.347 1 8% 12 0 View 3D
SFN Predictomes 0.018 7.37e-01 0.019 0.510 — — 8 0 View 3D
MAP2K1 Predictomes -0.152 4.06e-24 -0.381 0.310 0 0% 16 0 View 3D
RAF1 Predictomes -0.014 6.14e-01 -0.022 0.489 — — 14 0 View 3D
RRAS2 Predictomes 0.152 6.44e-32 0.462 0.731 0 0% 14 0 View 3D
YWHAB Predictomes 0.002 6.88e-01 -0.018 0.491 — — 14 0 View 3D
KSR2 Predictomes -0.012 5.06e-01 -0.029 0.485 — — 14 0 View 3D
KRAS Predictomes 0.142 2.69e-29 0.443 0.721 0 0% 14 0 View 3D
SFN Predictomes 0.022 4.34e-01 0.041 0.521 — — 9 0 View 3D
NRAS Predictomes 0.138 3.12e-28 0.432 0.716 0 0% 14 0 View 3D
KSR1 Predictomes 0.004 8.64e-01 0.008 0.504 — — 12 0 View 3D
YWHAZ Zhang_et_al 0.029 3.47e-01 0.068 0.534 — — 5 0 View 3D
A0A1B0GUL7 Zhang_et_al -0.180 1.72e-43 -0.486 0.257 0 0% 17 0 View 3D
EGFR Zhang_et_al -0.037 1.01e-02 -0.131 0.434 — — 9 0 View 3D
MAP2K2 Zhang_et_al -0.192 1.25e-47 -0.509 0.246 2 12% 17 0 View 3D
MAP2K1 Zhang_et_al -0.171 4.11e-19 -0.455 0.273 0 0% 8 0 View 3D
YWHAH Zhang_et_al -0.011 4.72e-01 -0.060 0.470 — — 4 0 View 3D
RABGGTB Zhang_et_al 0.037 7.25e-02 0.098 0.549 — — 8 0 View 3D