ARAF — Activity

🧬 View Structure

66 interactions

DMS Score Heatmap Scroll horizontally • click a column to see interactions • ■ purple strip = interface positions

RBD_ARAF C1_A_C-Raf STKc_A-Raf A V I L G F Y W C M P S T N Q D E H K R * 20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 520 540 560 580 600 0.18 1.00 2.65
Click a position to see interactions — ■ orange strip marks interface positions (darker = more interactions)

Significant Interactions

Interactor Predictor Log FC p-value (FDR) Cliff's Delta AUROC Unique Pos. % Unique # Interface Clashes Structure
KSR1 Predictomes -0.780 1.70e-44 -0.574 0.213 0 0% 13 0 View 3D
MAP2K1 Predictomes -0.215 6.09e-03 -0.115 0.442 0 0% 13 0 View 3D
YWHAH Predictomes 1.083 2.69e-06 0.192 0.596 0 0% 13 0 View 3D
BRAF Predictomes -0.908 2.39e-49 -0.648 0.176 0 0% 11 0 View 3D
YWHAH Predictomes 1.197 2.38e-08 0.237 0.618 0 0% 12 0 View 3D
RRAS2 Predictomes 0.259 3.63e-09 0.234 0.617 0 0% 14 0 View 3D
YWHAG Predictomes 1.052 1.09e-05 0.182 0.591 0 0% 13 0 View 3D
YWHAH Predictomes 1.127 1.84e-06 0.203 0.601 0 0% 12 0 View 3D
RAF1 Predictomes -0.845 2.70e-55 -0.613 0.194 0 0% 14 0 View 3D
RAF1 Predictomes -0.839 7.51e-54 -0.615 0.193 0 0% 14 0 View 3D
SFN Predictomes 1.560 1.12e-24 0.548 0.774 0 0% 7 0 View 3D
MAP2K3 Predictomes -0.589 1.91e-15 -0.398 0.301 0 0% 8 0 View 3D
MAP2K3 Predictomes -0.492 5.37e-12 -0.327 0.336 0 0% 9 0 View 3D
MAP2K2 Predictomes -0.069 2.42e-01 -0.049 0.475 0 0% 14 0 View 3D
MAP2K2 Predictomes -0.216 6.14e-03 -0.115 0.442 0 0% 13 0 View 3D
YWHAB Predictomes 1.312 1.76e-10 0.260 0.630 0 0% 13 0 View 3D
YWHAB Predictomes 0.915 1.61e-02 0.098 0.549 0 0% 14 0 View 3D
KSR1 Predictomes -0.759 2.29e-44 -0.564 0.218 0 0% 13 0 View 3D
MAP2K5 Predictomes -0.454 5.72e-13 -0.317 0.341 1 9% 11 0 View 3D
YWHAZ Predictomes 1.166 1.99e-07 0.221 0.610 0 0% 12 0 View 3D
RRAS Predictomes 0.013 5.67e-01 0.032 0.516 — — 8 0 View 3D
NRAS Predictomes 0.258 8.03e-09 0.228 0.614 0 0% 14 0 View 3D
YWHAZ Predictomes 1.090 1.85e-06 0.196 0.598 0 0% 13 0 View 3D
MAP2K5 Predictomes -0.619 1.98e-19 -0.427 0.286 1 9% 9 0 View 3D
NRAS Predictomes 0.253 1.21e-08 0.225 0.613 0 0% 14 0 View 3D
KRAS Predictomes 0.273 7.70e-10 0.241 0.620 0 0% 14 0 View 3D
MAP2K1 Predictomes -0.071 2.44e-01 -0.049 0.475 0 0% 14 0 View 3D
MAP2K2 Predictomes -0.248 8.78e-05 -0.153 0.423 0 0% 15 0 View 3D
MAP2K5 Predictomes -0.278 6.76e-08 -0.210 0.395 1 9% 15 0 View 3D
YWHAQ Predictomes 1.206 1.36e-08 0.240 0.620 0 0% 12 0 View 3D
KRAS Predictomes 0.257 8.46e-09 0.227 0.614 0 0% 14 0 View 3D
STK11 Predictomes -0.377 5.84e-09 -0.244 0.378 1 8% 12 0 View 3D
BRAF Predictomes -0.868 1.68e-47 -0.631 0.184 0 0% 11 0 View 3D
STK11 Predictomes -0.331 9.16e-07 -0.208 0.396 1 8% 12 0 View 3D
HRAS Predictomes 0.265 2.26e-09 0.235 0.617 0 0% 14 0 View 3D
YWHAQ Predictomes 1.069 6.70e-06 0.185 0.593 0 0% 13 0 View 3D
HRAS Predictomes 0.251 8.04e-08 0.226 0.613 0 0% 12 0 View 3D
KSR2 Predictomes -0.593 4.16e-32 -0.464 0.268 1 7% 14 0 View 3D
YWHAZ Predictomes 1.320 1.04e-10 0.263 0.632 0 0% 13 0 View 3D
RRAS2 Predictomes 0.263 1.23e-10 0.247 0.623 0 0% 15 0 View 3D
BRAF Predictomes -0.802 1.28e-49 -0.606 0.197 0 0% 13 0 View 3D
YWHAE Predictomes 1.191 5.57e-08 0.231 0.616 0 0% 12 0 View 3D
YWHAG Predictomes 1.413 2.22e-14 0.385 0.693 0 0% 8 0 View 3D
YWHAE Predictomes 1.093 2.96e-07 0.210 0.605 0 0% 13 0 View 3D
YWHAG Predictomes 1.498 6.89e-29 0.561 0.781 0 0% 8 0 View 3D
YWHAQ Predictomes 0.971 5.72e-03 0.120 0.560 0 0% 12 0 View 3D
YWHAE Predictomes 1.100 7.62e-06 0.191 0.595 0 0% 12 0 View 3D
MAP2K3 Predictomes -0.571 2.64e-14 -0.381 0.309 0 0% 8 0 View 3D
STK11 Predictomes -0.409 2.93e-09 -0.251 0.374 1 8% 12 0 View 3D
SFN Predictomes 1.509 1.53e-29 0.568 0.784 0 0% 8 0 View 3D
MAP2K1 Predictomes -0.230 7.82e-04 -0.129 0.435 0 0% 16 0 View 3D
RAF1 Predictomes -0.788 8.05e-52 -0.598 0.201 0 0% 14 0 View 3D
RRAS2 Predictomes 0.293 7.90e-11 0.255 0.628 0 0% 14 0 View 3D
YWHAB Predictomes 1.125 2.43e-10 0.252 0.626 0 0% 14 0 View 3D
KSR2 Predictomes -1.008 3.35e-61 -0.653 0.174 1 7% 14 0 View 3D
KRAS Predictomes 0.238 5.94e-08 0.214 0.607 0 0% 14 0 View 3D
SFN Predictomes 1.317 7.22e-16 0.386 0.693 0 0% 9 0 View 3D
NRAS Predictomes 0.265 2.24e-09 0.234 0.617 0 0% 14 0 View 3D
KSR1 Predictomes -0.922 2.08e-55 -0.656 0.172 0 0% 12 0 View 3D
YWHAZ Zhang_et_al 1.654 7.55e-15 0.484 0.742 1 20% 5 0 View 3D
A0A1B0GUL7 Zhang_et_al -0.337 3.88e-08 -0.197 0.401 0 0% 17 0 View 3D
EGFR Zhang_et_al -0.816 1.34e-39 -0.631 0.185 0 0% 9 0 View 3D
MAP2K2 Zhang_et_al -0.215 4.08e-10 -0.223 0.389 2 12% 17 0 View 3D
MAP2K1 Zhang_et_al -0.350 8.08e-07 -0.256 0.372 0 0% 8 0 View 3D
YWHAH Zhang_et_al 1.578 5.46e-10 0.438 0.719 2 50% 4 0 View 3D
RABGGTB Zhang_et_al 1.611 2.66e-22 0.484 0.742 3 38% 8 0 View 3D