EGFR — Activity

🧬 View Structure

73 interactions

DMS Score Heatmap Scroll horizontally • click a column to see interactions • ■ purple strip = interface positions

TM_ErbB1 PTKc_EGFR A V I L G F Y W C M P S T N Q D E H K R * 680 700 720 740 760 780 800 820 840 860 880 900 920 940 960 980 1000 1020 1040 1060 1080 1100 1180 1200 0.50 1.00 1.60
Click a position to see interactions — ■ orange strip marks interface positions (darker = more interactions)

Significant Interactions

Interactor Predictor Log FC p-value (FDR) Cliff's Delta AUROC Unique Pos. % Unique # Interface Clashes Structure
PPIB Predictomes -0.051 2.60e-01 -0.068 0.466 — — 7 0 View 3D
EGF Predictomes -0.080 1.18e-01 -0.108 0.446 — — 5 0 View 3D
ERRFI1 Predictomes -0.018 9.20e-01 0.004 0.502 — — 25 0 View 3D
SGSM2 Predictomes -0.065 1.13e-01 -0.124 0.438 — — 4 0 View 3D
EGF Predictomes -0.022 6.14e-01 0.027 0.513 — — 10 0 View 3D
ERBB2 Predictomes -0.039 8.78e-01 -0.007 0.496 — — 16 0 View 3D
ERBB3 Predictomes 0.095 2.87e-03 0.111 0.556 — — 19 0 View 3D
ERRFI1 Predictomes -0.018 9.92e-01 -0.000 0.500 — — 24 0 View 3D
SGSM2 Predictomes -0.041 5.74e-01 -0.031 0.484 — — 9 0 View 3D
PPIB Predictomes -0.047 4.89e-01 -0.037 0.482 — — 10 0 View 3D
PPIB Predictomes -0.052 2.90e-01 -0.064 0.468 — — 7 0 View 3D
ERRFI1 Predictomes -0.017 8.02e-01 0.010 0.505 — — 22 0 View 3D
ABL1 Predictomes -0.056 7.88e-01 -0.023 0.489 — — 4 0 View 3D
LSM11 Zhang_et_al -0.068 1.97e-01 -0.122 0.439 — — 3 0 View 3D
CTR9 Zhang_et_al -0.024 4.63e-01 0.029 0.515 — — 21 0 View 3D
BUB3 Zhang_et_al -0.050 5.65e-01 -0.051 0.475 — — 4 0 View 3D
B4GALT1 Zhang_et_al -0.073 4.29e-01 -0.077 0.461 — — 3 0 View 3D
CD2AP Zhang_et_al 0.012 4.99e-01 0.038 0.519 — — 10 0 View 3D
SH2B3 Zhang_et_al 0.085 2.04e-01 0.066 0.533 — — 10 0 View 3D
WDR44 Zhang_et_al -0.020 4.69e-01 0.037 0.519 — — 12 0 View 3D
NOTCH2 Zhang_et_al -0.046 7.15e-01 -0.030 0.485 — — 5 0 View 3D
NOTCH2 Zhang_et_al -0.051 7.30e-01 -0.033 0.483 — — 4 0 View 3D
NOTCH2 Zhang_et_al -0.032 9.00e-01 0.007 0.503 — — 13 0 View 3D
PIK3R4 Zhang_et_al -0.032 9.40e-01 0.004 0.502 — — 11 0 View 3D
IARS1 Zhang_et_al -0.022 9.03e-01 0.006 0.503 — — 13 0 View 3D
EPS15 Zhang_et_al -0.065 1.62e-01 -0.078 0.461 — — 9 0 View 3D
LRIG3 Zhang_et_al -0.065 2.08e-01 -0.080 0.460 — — 7 0 View 3D
ADAMTS9 Zhang_et_al -0.038 7.89e-01 -0.015 0.493 — — 12 0 View 3D
ADAMTS9 Zhang_et_al -0.026 9.13e-01 0.008 0.504 — — 6 0 View 3D
ITGB2 Zhang_et_al -0.031 9.30e-01 0.005 0.503 — — 9 0 View 3D
MYO9A Zhang_et_al -0.066 9.00e-02 -0.096 0.452 — — 9 0 View 3D
CTNNB1 Zhang_et_al -0.021 6.74e-01 0.038 0.519 — — 4 0 View 3D
CRKL Zhang_et_al -0.066 3.90e-01 -0.082 0.459 — — 3 0 View 3D
ITGA2B Zhang_et_al -0.044 2.90e-01 -0.063 0.469 — — 8 0 View 3D
KAT7 Zhang_et_al -0.034 5.81e-01 -0.032 0.484 — — 9 0 View 3D
PLAA Zhang_et_al -0.021 5.27e-01 0.056 0.528 — — 4 0 View 3D
CLP1 Zhang_et_al -0.056 2.00e-01 -0.063 0.469 — — 11 0 View 3D
ATP6V1H Zhang_et_al 0.083 1.62e-01 0.117 0.559 — — 4 0 View 3D
CBLC Zhang_et_al -0.049 2.54e-01 -0.082 0.459 — — 5 0 View 3D
FERMT1 Zhang_et_al -0.055 3.29e-01 -0.066 0.467 — — 6 0 View 3D
ARAF Zhang_et_al -0.064 1.61e-01 -0.088 0.456 — — 7 0 View 3D
MLST8 Zhang_et_al -0.021 9.63e-01 0.004 0.502 — — 4 0 View 3D
VAV2 Zhang_et_al -0.063 3.33e-01 -0.080 0.460 — — 4 0 View 3D
LRIG1 Zhang_et_al -0.012 6.08e-01 0.033 0.517 — — 8 0 View 3D
SOS1 Zhang_et_al 0.173 8.87e-03 0.134 0.567 — — 9 0 View 3D
GATB Zhang_et_al -0.088 1.84e-02 -0.144 0.428 — — 6 0 View 3D
TWF1 Zhang_et_al 0.100 6.13e-02 0.175 0.587 — — 3 0 View 3D
SOS2 Zhang_et_al -0.000 8.09e-01 0.023 0.511 — — 4 0 View 3D
SOS2 Zhang_et_al -0.032 8.02e-01 -0.018 0.491 — — 8 0 View 3D
CHIA Zhang_et_al -0.021 7.06e-01 0.028 0.514 — — 6 0 View 3D
EED Zhang_et_al -0.018 5.91e-01 0.055 0.527 — — 3 0 View 3D
ACOT9 Zhang_et_al 0.005 7.10e-01 0.028 0.514 — — 6 0 View 3D
JPH1 Zhang_et_al -0.046 8.34e-01 -0.014 0.493 — — 7 0 View 3D
ANKRD13A Zhang_et_al -0.007 1.42e-01 0.085 0.543 — — 8 0 View 3D
SEL1L Zhang_et_al -0.003 6.91e-01 0.025 0.512 — — 10 0 View 3D
NCK1 Zhang_et_al -0.062 2.08e-01 -0.125 0.438 — — 3 0 View 3D
JUP Zhang_et_al -0.044 8.02e-01 -0.016 0.492 — — 9 0 View 3D
MIOS Zhang_et_al 0.003 8.30e-01 0.017 0.508 — — 6 0 View 3D
CTNND1 Zhang_et_al -0.047 1.48e-01 -0.085 0.458 — — 8 0 View 3D
PTPRF Zhang_et_al -0.026 2.82e-01 -0.081 0.459 — — 5 0 View 3D
EGFR RCSB_PDB -0.050 1.22e-01 -0.074 0.463 4 100% 11 0 View 3D
EGFR RCSB_PDB -0.075 4.93e-02 -0.090 0.455 4 100% 12 0 View 3D
ERRFI1 RCSB_PDB -0.025 9.92e-01 -0.000 0.500 — — 23 0 View 3D
ERBB3 RCSB_PDB 0.082 4.20e-02 0.074 0.537 — — 20 0 View 3D
EGFR RCSB_PDB -0.057 8.86e-02 -0.082 0.459 4 100% 11 0 View 3D
EGFR RCSB_PDB -0.068 7.77e-02 -0.084 0.458 4 100% 11 0 View 3D
ERBB3 RCSB_PDB 0.072 3.69e-02 0.073 0.536 — — 22 0 View 3D
ERBB3 RCSB_PDB 0.070 6.24e-02 0.068 0.534 — — 20 0 View 3D
EGFR RCSB_PDB 0.245 1.02e-04 0.276 0.638 4 100% 4 0 View 3D
EGFR RCSB_PDB -0.083 4.23e-02 -0.093 0.454 4 100% 12 0 View 3D
EGFR RCSB_PDB -0.080 6.75e-02 -0.087 0.456 4 100% 11 0 View 3D
EGFR RCSB_PDB 0.240 1.88e-04 0.265 0.633 4 100% 4 0 View 3D
ERRFI1 RCSB_PDB -0.010 7.77e-01 0.014 0.507 — — 13 0 View 3D