RET — Activity

🧬 View Structure

20 interactions

DMS Score Heatmap Scroll horizontally • click a column to see interactions • ■ purple strip = interface positions

PTKc_RET A V I L G F Y W C M P S T N Q D E H K R * 660 680 700 720 740 760 780 800 820 840 860 880 900 920 940 960 980 1000 1020 1040 1060 1080 1100 0.50 1.00 3.21
Click a position to see interactions — ■ orange strip marks interface positions (darker = more interactions)

Significant Interactions

Interactor Predictor Log FC p-value (FDR) Cliff's Delta AUROC Unique Pos. % Unique # Interface Clashes Structure
GFRA1 Predictomes -0.223 2.21e-01 -0.090 0.455 — — 4 0 View 3D
PLCG1 Predictomes 0.191 1.00e-12 0.356 0.678 8 100% 8 0 View 3D
PLCG1 Predictomes 0.187 3.22e-11 0.316 0.658 8 100% 9 0 View 3D
NTRK1 Predictomes -0.175 7.50e-01 -0.029 0.485 — — 3 0 View 3D
SORL1 Zhang_et_al -0.265 2.15e-06 -0.245 0.378 8 100% 8 0 View 3D
SORL1 Zhang_et_al -0.454 5.10e-16 -0.437 0.281 8 100% 7 0 View 3D
PTPRA Zhang_et_al -0.329 3.88e-07 -0.323 0.339 1 20% 5 0 View 3D
GNPTAB Zhang_et_al 0.162 7.78e-22 0.474 0.737 4 50% 8 0 View 3D
RAPH1 Zhang_et_al 0.258 1.36e-20 0.528 0.764 1 17% 6 0 View 3D
CBLC Zhang_et_al 0.195 2.07e-14 0.528 0.764 4 100% 4 0 View 3D
RET RCSB_PDB -0.237 8.03e-26 -0.344 0.328 18 86% 21 0 View 3D
RET RCSB_PDB -0.385 4.08e-35 -0.414 0.293 18 86% 20 0 View 3D
RET RCSB_PDB -0.318 8.83e-32 -0.376 0.312 18 86% 22 0 View 3D
RET RCSB_PDB -0.366 1.44e-34 -0.397 0.302 18 86% 22 0 View 3D
RET RCSB_PDB -0.299 1.32e-24 -0.343 0.328 18 86% 20 0 View 3D
RET RCSB_PDB -0.314 9.48e-25 -0.358 0.321 18 86% 18 0 View 3D
RET RCSB_PDB -0.289 4.18e-26 -0.353 0.323 18 86% 20 0 View 3D
RET RCSB_PDB -0.343 2.74e-30 -0.375 0.312 18 86% 21 0 View 3D
RET RCSB_PDB -0.226 1.24e-22 -0.334 0.333 18 86% 19 0 View 3D
RET RCSB_PDB -0.328 2.45e-26 -0.370 0.315 18 86% 18 0 View 3D